Paola Infante | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
A simplified genomic profiling approach predicts outcome in metastatic colorectal cancer	CANCERS	2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP	NATURE COMMUNICATIONS	2019
Targeting hedgehog signalling through the ubiquitylation process: the multiple roles of the HECT-E3 ligase itch	CELLS	2019
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth	CANCERS	2019
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2	ONCOGENESIS	2019
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors	SCIENTIFIC REPORTS	2019
Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH	2019
1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma	CELL COMMUNICATION AND SIGNALING	2019
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2018
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis	NATURE COMMUNICATIONS	2018
Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2018
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors	CELL DEATH & DISEASE	2018
Natural products inspired modulators of cancer stem cells-specific signaling pathways notch and hedgehog	CURRENT PHARMACEUTICAL DESIGN	2018
Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapy in vitro	NANOMEDICINE	2017
β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells	BMC CANCER	2017
The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint	ONCOTARGET	2016
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype	CELL DEATH & DISEASE	2016
SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development	EMBO JOURNAL	2016
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors	EMBO JOURNAL	2015
Non-canonical Hedgehog/ampk-mediated control of polyamine metabolism supports neuronal and medulloblastoma cell growth	DEVELOPMENTAL CELL	2015