Martina Leopizzi

Pubblicazioni

Titolo Pubblicato in Anno
PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey TUMORI 2024
The effect of cellular nuclear function alteration on the pathogenesis of shoulder adhesive capsulitis: an immunohistochemical study on lamin A/C expression JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY 2024
Toll-Like Receptor 4-Dependent Platelet-Related Thrombosis in SARS-CoV-2 Infection CIRCULATION RESEARCH 2023
Involvement of Substance P (SP) and Its Related NK1 Receptor in Primary Sjögren’s Syndrome (pSS) Pathogenesis CELLS 2023
Epstein-Barr virus encoded EBNA2 downregulates ICOSL by inducing miR-24 in B-cell lymphoma BLOOD 2023
PD-L1 testing in metastatic triple negative breast cancer: Results of an Italian survey TUMORI 2023
PAD4-Induced NETosis Via Cathepsin G-Mediated Platelet-Neutrophil Interaction in ChAdOx1 Vaccine-Induced Thrombosis-Brief Report ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY 2023
Vaccine-induced immune thrombotic thrombocytopenia: a possible pathogenetic role of ChAdOx1 nCoV-19 vaccine encoded soluble SARS-CoV-2 spike protein HAEMATOLOGICA 2022
Harpagophytum procumbens root extract mediates anti-inflammatory effects in osteoarthritis synoviocytes through CB2 activation PHARMACEUTICALS 2022
Evidence of SARS-CoV-2 spike protein on retrieved thrombi from COVID-19 patients JOURNAL OF HEMATOLOGY & ONCOLOGY 2022
MRI- and Histologic-Molecular-Based Radio-Genomics Nomogram for Preoperative Assessment of Risk Classes in Endometrial Cancer CANCERS 2022
Radical surgery after neoadjuvant chemotherapy for locally advanced neuroendocrine cancer of the cervix ANTICANCER RESEARCH 2021
Nuclear lamin A in rotator cuff tear margin tenocytes: an antiapoptotic and cell mechanostat factor JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH 2021
The Glucosamine-derivative NAPA Suppresses MAPK Activation and Restores Collagen Deposition in Human Diploid Fibroblasts Challenged with Environmental Levels of UVB PHOTOCHEMISTRY AND PHOTOBIOLOGY 2020
Mesenchymal cystic hamartoma presenting with pneumothorax: case report and review of the literature GENERAL THORACIC AND CARDIOVASCULAR SURGERY 2020
Nuclear functions of the tyrosine kinase Src INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Phosphoinositide-specific phospholipase C isoforms are conveyed by osteosarcoma-derived extracellular vesicles JOURNAL OF CELL COMMUNICATION AND SIGNALING 2020
Antiarthritic effects of a root extract from harpagophytum procumbens dc: novel insights into the molecular mechanisms and possible bioactive phytochemicals NUTRIENTS 2020
PD-L1 expression is associated with tumor infiltrating lymphocytes that predict response to NACT in squamous cell cervical cancer VIRCHOWS ARCHIV 2020
Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse JOURNAL OF CELLULAR BIOCHEMISTRY 2019

ERC

  • LS1_9
  • LS3_3
  • LS3_5
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

The scientific activity of Dr. Leopizzi  has been focused on bone disease, in particular on the study of the onset and progression of Osteosarcoma analyzing different  processes in human osteosarcoma tissues and cell lines (primary and immortalized). In this contest, she studied different proteins – Ezrin, Rho and Ras GTPase - aiming in understanding the new targets and molecules involved in the pathogenesis of osteosarcoma.

She is also studying the relationships between Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes in osteosarcoma to elucidate the role of the signalling pathways in pathologic processes including cancer cell migration, invasion, and metastasis.  Furthermore she characterized the expression and subcellular localization of Phosphoinositide-specific Phospholipase C enzymes in differently polarized macrophages, in osteoblast cells, in fibroblast cells and in other bone cancer as Ewing Sarcoma and Synovial Sarcoma.

Recently, she started to study osteosarcoma-derived extracellular vesicles and demonstrated that PI-PLC isoforms localize into cell membrane extracellular vesicles about to be released, as conveyed and/or membrane protein.

Keywords

PI-PLC
Osteosarcoma
bone
biologia cellulare
cell signalling
osteoblasts
kidney

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