Martina Leopizzi

Pubblicazioni

Titolo Pubblicato in Anno
Vaccine-induced immune thrombotic thrombocytopenia: a possible pathogenetic role of ChAdOx1 nCoV-19 vaccine encoded soluble SARS-CoV-2 spike protein HAEMATOLOGICA 2022
Harpagophytum procumbens root extract mediates anti-inflammatory effects in osteoarthritis synoviocytes through CB2 activation PHARMACEUTICALS 2022
Radical surgery after neoadjuvant chemotherapy for locally advanced neuroendocrine cancer of the cervix ANTICANCER RESEARCH 2021
The Glucosamine-derivative NAPA Suppresses MAPK Activation and Restores Collagen Deposition in Human Diploid Fibroblasts Challenged with Environmental Levels of UVB PHOTOCHEMISTRY AND PHOTOBIOLOGY 2020
Mesenchymal cystic hamartoma presenting with pneumothorax: case report and review of the literature GENERAL THORACIC AND CARDIOVASCULAR SURGERY 2020
Nuclear functions of the tyrosine kinase Src INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Phosphoinositide-specific phospholipase C isoforms are conveyed by osteosarcoma-derived extracellular vesicles JOURNAL OF CELL COMMUNICATION AND SIGNALING 2020
Antiarthritic effects of a root extract from harpagophytum procumbens dc: novel insights into the molecular mechanisms and possible bioactive phytochemicals NUTRIENTS 2020
PD-L1 expression is associated with tumor infiltrating lymphocytes that predict response to NACT in squamous cell cervical cancer VIRCHOWS ARCHIV 2020
Phosphoinositide-specific phospholipase C in normal human liver and in alcohol abuse JOURNAL OF CELLULAR BIOCHEMISTRY 2019
Sclerostin is expressed in the atherosclerotic plaques of patients who undergoing carotid endarterectomy DIABETES/METABOLISM RESEARCH AND REVIEWS 2019
The attempt of spontaneous repair of rotator cuff tear: the role of periostin JOURNAL OF ORTHOPAEDICS 2019
On the role of skin biopsy in the diagnosis of calcific uremic arteriolopathy. A case-based discussion JN. JOURNAL OF NEPHROLOGY 2019
Effect of different drug classes on reverse remodeling of intramural coronary arterioles in the spontaneously hypertensive rat MICROCIRCULATION 2017
Wounds difficult to heal. An effective treatment strategy CURRENT VASCULAR PHARMACOLOGY 2017
IKKα inibition by a glucosamine derivative enhances maspin expression in osteosarcoma cell line CHEMICO-BIOLOGICAL INTERACTIONS 2017
LPS, Oleuropein and Blueberry extracts affect the survival, morphology and Phosphoinositide signalling in stimulated human endothelial cells JOURNAL OF CELL COMMUNICATION AND SIGNALING 2017
Different expression and localization of phosphoinositide specific phospholipases C in human osteoblasts, osteosarcoma cell lines, Ewing sarcoma and synovial sarcoma AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY 2017
Comparison of phosphoinositide-specific phospholipase c panel of expression of human osteoblasts versus mg-63 and saos osteoblast-like cells AVICENNA JOURNAL OF MEDICAL BIOCHEMISTRY 2016
U-73122 reduces the cell growth in cultured MG-63 ostesarcoma cell line involving Phosphoinositide-specific Phospholipases C SPRINGERPLUS 2016

ERC

  • LS1_9
  • LS3_3
  • LS3_5
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

The scientific activity of Dr. Leopizzi  has been focused on bone disease, in particular on the study of the onset and progression of Osteosarcoma analyzing different  processes in human osteosarcoma tissues and cell lines (primary and immortalized). In this contest, she studied different proteins – Ezrin, Rho and Ras GTPase - aiming in understanding the new targets and molecules involved in the pathogenesis of osteosarcoma.

She is also studying the relationships between Phosphoinositide-specific Phospholipase C (PI-PLC) enzymes in osteosarcoma to elucidate the role of the signalling pathways in pathologic processes including cancer cell migration, invasion, and metastasis.  Furthermore she characterized the expression and subcellular localization of Phosphoinositide-specific Phospholipase C enzymes in differently polarized macrophages, in osteoblast cells, in fibroblast cells and in other bone cancer as Ewing Sarcoma and Synovial Sarcoma.

Recently, she started to study osteosarcoma-derived extracellular vesicles and demonstrated that PI-PLC isoforms localize into cell membrane extracellular vesicles about to be released, as conveyed and/or membrane protein.

Keywords

PI-PLC
Osteosarcoma
bone
biologia cellulare
cell signalling
osteoblasts
kidney

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