Ricerc@Sapienza

The research activity is mainly focused on the study of  muscle wasting and neurodegeneration. In particular the studies are focused on the analysis of the molecular pathways activated by the Insulin like Growth Factor 1 (IGF1) to counteract muscle atrophy associated with aging and with Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disorder.  In particular the scientific research aims to investigate the contribute of skeletal muscle in ALS pathogenesis and the effects of localized accumulation of oxidative stress in muscle and nerve interplay, dissecting the molecular mechanism underpinning skeletal muscle and nervous tissue communication. One of the main features of neuromuscular disorders is the alteration of the metabolic homeostasis; therefore another field of interest is centred on the studies of the circadian metabolic profile during muscle and nerve differentiation in physiological and pathological condition such as in ALS disease.