Valentina Noemi Madia

Pubblicazioni

Titolo Pubblicato in Anno
Recent advances in recovery of lycopene from tomato waste. A potent antioxidant with endless benefits MOLECULES 2021
Toxicological aspects of cannabinoid, pesticide and metal levels detected in light Cannabis inflorescences grown in Italy FOOD AND CHEMICAL TOXICOLOGY 2021
Small-molecule inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H function. Challenges and recent developments CURRENT MEDICINAL CHEMISTRY 2021
New pyrimidine and pyridine derivatives as multitarget cholinesterase inhibitors. Design, synthesis, and in vitro and in cellulo evaluation ACS CHEMICAL NEUROSCIENCE 2021
Discovery of a pyrimidine compound endowed with antitumor activity INVESTIGATIONAL NEW DRUGS 2020
Pyrrolyl pyrazoles as non-diketo acid inhibitors of the HIV-1 ribonuclease H function of reverse transcriptase ACS MEDICINAL CHEMISTRY LETTERS 2020
In vitro antiviral activity of new oxazoline derivatives as potent poliovirus inhibitors JOURNAL OF MEDICINAL CHEMISTRY 2019
Design, synthesis, and biological evaluation of new 1-(aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives as antiprotozoal agents JOURNAL OF MEDICINAL CHEMISTRY 2019
Comparison of different methods for the extraction of cannabinoids from cannabis NATURAL PRODUCT RESEARCH 2019
Inhibition of Polycomb Repressive Complex2 activity reduces trimethylation of H3K27 and affects development in Arabidopsis seedlings BMC PLANT BIOLOGY 2019
Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism AMINO ACIDS 2019
Towards a new application of amaranth seed oil as an agent against Candida albicans NATURAL PRODUCT RESEARCH 2019
Tegaserod for the treatment of Irritable Bowel syndrome ANTI-INFLAMMATORY & ANTI-ALLERGY AGENTS IN MEDICINAL CHEMISTRY 2019
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
Novel benzazole derivatives endowed with potent antiheparanase activity JOURNAL OF MEDICINAL CHEMISTRY 2018
Novel symmetrical benzazolyl derivatives endowed with potent anti-heparanase activity JOURNAL OF MEDICINAL CHEMISTRY 2018
Inhibition of Leishmania infantum trypanothione reductase by diaryl sulfide derivatives JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
Structure-activity relationships on cynnamoyl derivatives as inhibitors of p300 Histone acetyltransferase CHEMMEDCHEM 2017
New insights into the interaction between pyrrolyl diketoacids and HIV-1 integrase active site and comparison with RNase H ANTIVIRAL RESEARCH 2016
N‑substituted quinolinonyl diketo acid derivatives as HIV integrase strand transfer inhibitors and their activity against RNase H function of reverse transcriptase JOURNAL OF MEDICINAL CHEMISTRY 2015

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Drug Design.

Antimicrobial agents active agains virues such as HIV, SARSCoV, HCV, CHIKV,

Antibacterial agents based on quinolone scaffold. Metallo-beta-lactamase inhibitors.

Antiprotozoals

Antifungals

Antimycobacterals

Antitumor agenst with specific mechanism of action: Kinase Inhibitors. Inhibitors of tubulin polimerization. Antitumoral agents found by phenotypic approach.

Natural substances: plant extracts for medicinal and nutraceutical applications.

Keywords

drug design and synthesis.
antiviral agents
antibacterial agents
antifungal agents
Antiprotozoal Agents
antimycobacterial agents
antitumor agents

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