Ilaria D'Acquarica


Titolo Pubblicato in Anno
The Quest for Secondary Pharmaceuticals: Drug Repurposing/Chiral-Switches Combination Strategy ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE 2023
Chiral distinction between hydroxychloroquine enantiomers in binding to angiotensin-converting enzyme 2, the forward receptor of SARS-CoV-2 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2023
Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19 DRUG DISCOVERY TODAY 2020
The market of chiral drugs: chiral switches versus de novo enantiomerically pure compounds JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2018
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61 JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2018
Naturally occurring diels-alder-type adducts from morus nigra as potent inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer PHARMACOLOGICAL RESEARCH 2018
Synthesis of bromoundecyl resorc[4]arenes and applications of the cone stereoisomer as selector for liquid chromatography JOURNAL OF ORGANIC CHEMISTRY 2018
Cannabis through the looking glass: chemo- and enantio-selective separation of phytocannabinoids by enantioselective ultra high performance supercritical fluid chromatography CHEMICAL COMMUNICATIONS 2017
Green routes for the production of enantiopure benzylisoquinoline alkaloids INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2017
First Detection of a Ruthenium-Carbene-Resorc[4]arene Complex During the Progress of a Metathesis Reaction EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2017
Chiral Separations. Chiral Dynamic Chromatography in the Study of Stereolabile Compounds Handbook of Advanced Chromatography/ Mass Spectrometry Techniques 2017
Occurrence of enantioselectivity in nature: The case of (S)-norcoclaurine CHIRALITY 2016
The Pictet-Spengler Reaction Still On Stage CURRENT PHARMACEUTICAL DESIGN 2016
Molecular recognition of natural products by resorc[4]arene receptors CURRENT PHARMACEUTICAL DESIGN 2016
A novel enzymatic strategy for the synthesis of substituted tetrahydroisoquinolines CHEMISTRYSELECT 2016
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype CELL DEATH & DISEASE 2016
Total Synthesis of (±)-Kuwanol E JOURNAL OF NATURAL PRODUCTS 2016
Resorc[4]arenes as preorganized synthons for surface recognition and host-guest chemistry Calixarenes and Beyond 2016


  • LS1_9
  • PE4_2
  • PE5_16
  • PE5_17


  • Advanced manufacturing & processing
  • Advanced materials
  • Sustainable technologies & development

Interessi di ricerca

  1. Preparazione di supporti di natura silicea per cromatografia liquida a elevate prestazioni (HPLC e UHPLC). 
  2. Separazioni cromatografiche di sostanze chirali biologicamente attive (farmaci, intermedi di reazione, metaboliti presenti in fluidi biologici, estratti vegetali).
  3. Studi di ricognizione molecolare enantioselettiva in fase gassosa su resorc[4]areni chirali.
  4. Purificazione e caratterizzazione di prodotti naturali con attività antitumorale attivi sulla via di trasduzione del segnale di Hedgehog.
  5. Farmaci chirali e loro autorizzazione all’immissione in commercio da parte degli enti regolatori europei e americani


separation technology
organic chemistry
chiral drugs
natural products
enantioselective high-performance liquid chromatography

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