Rossella Benedetti


Titolo Pubblicato in Anno
Different outcome of targeting ERN1/IRE1 alpha and EIF2AK3/PERK in NSG mice engrafted with primary effusion lymphoma BRITISH JOURNAL OF HAEMATOLOGY 2023
The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice MICROBIOLOGY SPECTRUM 2023
DNA damage triggers an interplay between wtp53 and c-Myc affecting lymphoma cell proliferation and Kaposi sarcoma herpesvirus replication BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2022
VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
The dysregulation of autophagy and ER stress induced by HHV-6A infection activates pro-inflammatory pathways and promotes the release of inflammatory cytokines and cathepsin S by CNS cells VIRUS RESEARCH 2022
Targeting c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple Myeloma Cells BIOMEDICINES 2022
The impairment of DDR reduces XBP1s, further increasing DNA damage, and triggers autophagy via PERK/eIF2alpha in MM and IRE1alpha/JNK1/2 in PEL cells BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2022
p62/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation CARCINOGENESIS 2022
c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway BIOMEDICINES 2022
Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress CELL DEATH DISCOVERY 2022
P53‐r273h sustains ros, pro‐inflammatory cytokine release and mtor activation while reducing autophagy, mitophagy and ucp2 expression, effects prevented by wtp53 BIOMOLECULES 2021
The cross-talk between STAT1/STAT3 and ROS up-regulates PD-L1 and promotes the release of pro-inflammatory/immune suppressive cytokines in primary monocytes infected by HHV-6B VIRUS RESEARCH 2021
PGE2 released by pancreatic cancer cells undergoing ER stress transfers the stress to DCs impairing their immune function MOLECULAR CANCER THERAPEUTICS 2021
Role of upr sensor activation in cell death–survival decision of colon cancer cells stressed by dpe treatment BIOMEDICINES 2021
Anticancer effect of AZD2461 PARP inhibitor against colon cancer cells carrying wt or dysfunctional p53 EXPERIMENTAL CELL RESEARCH 2021
New insights into curcumin-and resveratrol-mediated anti-cancer effects PHARMACEUTICALS 2021
PBA preferentially impairs cell survival of glioblastomas carrying mutp53 by reducing its expression level, stabilizing wtp53, downregulating the mevalonate kinase and dysregulating UPR BIOMOLECULES 2020
STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway FRONTIERS IN ONCOLOGY 2020
Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV CELLS 2020


  • LS3_2
  • LS4_12


  • Life-science technologies & biotechnologies


endoplasmic reticulum (ER stress)
mutant p53 (mutp53)

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