Loretta Tuosto | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
CD28 and associated class 1A P13K regulates the glycolytic metabolic program associated to pro-inflammatory T cell responses in Multiple Sclerosis	EUROPEAN JOURNAL OF IMMUNOLOGY	2019
CD28	Encyclopedia of Signaling Molecules. Second Edition	2018
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28	NATURE COMMUNICATIONS	2018
CD28 between tolerance and autoimmunity: The side effects of animal models [version 1; referees: 2 approved]	F1000RESEARCH	2018
Editorial: Membrane lipids in T cell functions	FRONTIERS IN IMMUNOLOGY	2018
ISA-2011B, a phosphatidylinositol 4-phosphate 5-kinase a inhibitor, impairs CD28-dependent costimulatory and pro-inflammatory signals in human T lymphocytes	FRONTIERS IN IMMUNOLOGY	2017
CD28 costimulatory signals in T lymphocyte activation: Emerging functions beyond a qualitative and quantitative support to TCR signalling	CYTOKINE & GROWTH FACTOR REVIEWS	2016
Phosphatidylinositol 4-Phosphate 5-Kinases in the Regulation of T Cell Activation	FRONTIERS IN IMMUNOLOGY	2016
Phosphatidylinositol 4-phosphate 5-kinase β controls recruitment of lipid rafts into the immunological synapse	JOURNAL OF IMMUNOLOGY	2016
Phosphatidylinositol 4-phosphate 5-kinase α and Vav1 mutual cooperation in CD28-mediated actin remodeling and signaling functions	JOURNAL OF IMMUNOLOGY	2015
Targeting Inflammatory T Cells in Multiple Sclerosis: Current Therapies and Future Challenges	AUSTIN JOURNAL OF MULTIPLE SCLEROSIS & NEUROIMMUNOLOGY	2015
The multifaceted role of PIP2 in leukocyte biology	CELLULAR AND MOLECULAR LIFE SCIENCES	2015

Progetti di Ricerca

Bacterial superantigens in inflammatory autoimmune diseases: therapeutic targeting of CD28 costimulatory pathway to modulate excessive T cell inflammatory responses
Characterization of the signalling motifs of human CD28 involved in the lethal inflammatory responses to bacterial superantigen toxins
Role of CD28 and associated class 1A PI3K in the regulation of the cellular metabolic programs associated to pro-inflammatory T cell responses
Role of IL-6 and NF-kB signalling mediators in CD28-induced IL-17A gene expression and Th17 cell subset expansion
Role of CD28 and associated class 1A PI3K in the regulation of IL-22 production and IL-22-producing T cell amplification

Gruppi di ricerca - Responsabile

Immunologia Cellulare e Mlecolare