Ricerc@Sapienza

Progetti di Ricerca

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  Bacterial superantigens in inflammatory autoimmune diseases: therapeutic targeting of CD28 costimulatory pathway to modulate excessive T cell inflammatory responses

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  Characterization of the signalling motifs of human CD28 involved in the lethal inflammatory responses to bacterial superantigen toxins

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  Role of CD28 and associated class 1A PI3K in the regulation of the cellular metabolic programs associated to pro-inflammatory T cell responses

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  Role of IL-6 and NF-kB signalling mediators in CD28-induced IL-17A gene expression and Th17 cell subset expansion

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  Role of CD28 and associated class 1A PI3K in the regulation of IL-22 production and IL-22-producing T cell amplification