Loretta Tuosto | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions	FRONTIERS IN IMMUNOLOGY	2024
Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells	FRONTIERS IN IMMUNOLOGY	2023
ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
Astrocytes and inflammatory T Helper Cells: a dangerous liaison in Multiple Sclerosis	FRONTIERS IN IMMUNOLOGY	2022
CD8+ T Cell Senescence: Lights and Shadows in Viral Infections, Autoimmune Disorders and Cancer	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity	CELLS	2022
Editorial: Insights in T Cell Biology: 2021	FRONTIERS IN IMMUNOLOGY	2022
Binding of Staphylococcal Enterotoxin B (SEB) to B7 Receptors Triggers TCR- and CD28-Mediated Inflammatory Signals in the Absence of MHC Class II Molecules	FRONTIERS IN IMMUNOLOGY	2021
Staphylococcal enterotoxin B (SEB) activates TCR- and CD28-mediated inflammatory signals in the absence of MHC class II molecules	6th European Congress of Immunology, 1–4 September 2021, Virtual meetingEUROPEAN JOURNAL OF IMMUNOLOGY	2021
CD28 individual signaling up-regulates IL-22 expression and IL-22-mediated effector functions in human T lymphocytes	6th European Congress of Immunology, 1-4 September 2021, Virtual meetingEUROPEAN JOURNAL OF IMMUNOLOGY	2021
T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis	CELLS	2020
Safety and efficacy of the Russian COVID-19 vaccine: more information needed	THE LANCET	2020
CD28 autonomous signaling orchestrates IL-22 expression and IL-22-regulated epithelial barrier functions in human T lymphocytes	FRONTIERS IN IMMUNOLOGY	2020
The Impact of the 'Mis-Peptidome' on HLA Class I-Mediated Diseases: Contribution of ERAP1 and ERAP2 and Effects on the Immune Response	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2020
CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter	FRONTIERS IN IMMUNOLOGY	2019
CD28 Autonomous Signaling Up-Regulates C-Myc Expression and Promotes Glycolysis Enabling Inflammatory T Cell Responses in Multiple Sclerosis	CELLS	2019
ReIA/NF-kB and STAT3 transcription factors cooperate in trans-activating the human IL-17A proximal promoter in response to CD28 individual stimulation	EUROPEAN JOURNAL OF IMMUNOLOGY	2019
CD28 and associated class 1A P13K regulates the glycolytic metabolic program associated to pro-inflammatory T cell responses in Multiple Sclerosis	EUROPEAN JOURNAL OF IMMUNOLOGY	2019
CD28	Encyclopedia of Signaling Molecules. Second Edition	2018
A non-conserved amino acid variant regulates differential signalling between human and mouse CD28	NATURE COMMUNICATIONS	2018

Progetti di Ricerca

Bacterial superantigens in inflammatory autoimmune diseases: therapeutic targeting of CD28 costimulatory pathway to modulate excessive T cell inflammatory responses
Characterization of the signalling motifs of human CD28 involved in the lethal inflammatory responses to bacterial superantigen toxins
Role of CD28 and associated class 1A PI3K in the regulation of the cellular metabolic programs associated to pro-inflammatory T cell responses
Role of IL-6 and NF-kB signalling mediators in CD28-induced IL-17A gene expression and Th17 cell subset expansion
Role of CD28 and associated class 1A PI3K in the regulation of IL-22 production and IL-22-producing T cell amplification

Gruppi di ricerca - Responsabile

Immunologia Cellulare e Mlecolare