Francesca Cutruzzola'

Pubblicazioni

Titolo Pubblicato in Anno
Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa THE FEBS JOURNAL 2018
The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells THE FEBS JOURNAL 2018
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa PROTEINS 2018
Human cytosolic and mitochondrial serine hydroxymethyltransferase isoforms in comparison: full kinetic characterization and substrate inhibition properties BIOCHEMISTRY 2018
Glucose metabolism in the progression of prostate cancer FRONTIERS IN PHYSIOLOGY 2017
Radiation damage at the active site of human alanine:glyoxylate aminotransferase reveals that the cofactor position is finely tuned during catalysis SCIENTIFIC REPORTS 2017
Discovering selective diguanylate cyclase inhibitors: From PleD to discrimination of the active site of cyclic-di-GMP phosphodiesterases c-di-GMP signaling 2017
CHAPTER 4: Nitrite Reductase - Cytochrome cd1 RSC Metallobiology 2017
Origin and impact of nitric oxide in Pseudomonas aeruginosa biofilms JOURNAL OF BACTERIOLOGY 2016
In silico discovery and in vitro validation of catechol-containing sulfonohydrazide compounds as potent inhibitors of the diguanylate cyclase PleD JOURNAL OF BACTERIOLOGY 2016
Novel genetic tools to tackle c-di-GMP-dependent signaling in Pseudomonas aeruginosa JOURNAL OF APPLIED MICROBIOLOGY 2016
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic hydroxymethyltransferase and induces cell death in lung cancer cells ONCOTARGET 2016
Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 2016
How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state THE FEBS JOURNAL 2015
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase CHEMMEDCHEM 2015
Structural basis of functional diversification of the HD-GYP domain revealed by the pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site JOURNAL OF BACTERIOLOGY 2015
Synthesis of triazole-linked analogues of c-di-gmp and their interactions with diguanylate cyclase JOURNAL OF MEDICINAL CHEMISTRY 2015

ERC

  • LS1
  • LS1_1
  • LS1_2
  • LS1_3
  • LS1_9
  • LS4_9
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Progetti di Ricerca

Gruppi di ricerca

Nutrient sensing and redox transducers in bacterial biofilm.

Gruppi di ricerca - Responsabile

RNA-mediated modulation of cell metabolism
Nucleotide and aminoacid metabolism in cancer and other pathological states

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