Carlo Massimo Casciola


Titolo Pubblicato in Anno
Microfluidic fiber spinning for 3D bioprinting: Harnessing microchannels to build macrotissues INTERNATIONAL JOURNAL OF BIOPRINTING 2024
The local variation of the Gaussian modulus enables different pathways for fluid lipid vesicle fusion SCIENTIFIC REPORTS 2024
Diffuse interface modeling of laser-induced nano/micro cavitation bubbles PHYSICS OF FLUIDS 2023
Classical nucleation of vapor between hydrophobic plates THE JOURNAL OF CHEMICAL PHYSICS 2023
The role of polymer parameters and configurations in drag-reduced turbulent wall-bounded flows: Comparison between FENE and FENE-P INTERNATIONAL JOURNAL OF MULTIPHASE FLOW 2023
Kinetic Energy Budget in Turbulent Flows of Dilute Polymer Solutions FLOW TURBULENCE AND COMBUSTION 2023
Drag increase and turbulence augmentation in two-way coupled particle-laden wall-bounded flows PHYSICS OF FLUIDS 2023
A nanoscale view of the origin of boiling and its dynamics NATURE COMMUNICATIONS 2023
Detection of Pathological Markers of Neurodegenerative Diseases following Microfluidic Direct Conversion of Patient Fibroblasts into Neurons INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Heterogeneous cavitation from atomically smooth liquid–liquid interfaces NATURE PHYSICS 2022
Drag reduction in turbulent wall-bounded flows of realistic polymer solutions PHYSICAL REVIEW LETTERS 2022
Activation energy and force fields during topological transitions of fluid lipid vesicles COMMUNICATIONS PHYSICS 2022
Cavitation over solid surfaces: microbubble collapse, shock waves, and elastic response MECCANICA 2022
Vapor Nucleation in Metastable Liquids: the Continuum Description The Surface Wettability Effect on Phase Change 2022
Drag Reduction in Polymer-Laden Turbulent Pipe Flow FLUIDS 2022
Superhydrophobic surfaces to reduce form drag in turbulent separated flows AIP ADVANCES 2022
EH-DPD: a dissipative particle dynamics approach to electrohydrodynamics THE EUROPEAN PHYSICAL JOURNAL PLUS 2022
Turning molecular springs into nano-shock absorbers: the effect of macroscopic morphology and crystal size on the dynamic hysteresis of water intrusion-extrusion into-from hydrophobic nanopores ACS APPLIED MATERIALS & INTERFACES 2022
Tumor-on-a-chip platforms to study cancer-immune system crosstalk in the era of immunotherapy LAB ON A CHIP 2021
Heterogeneous bubble nucleation dynamics JOURNAL OF FLUID MECHANICS 2021


  • PE8_5


  • Nanotecnologie
  • Big data & computing

Interessi di ricerca

CMC coordinates a research group operating in the field of complex fluids. Under the PI’s guidance, the group dealt with theoretical, numerical, and experimental aspects of fluid mechanics, to be understood in a wide sense, ranging from scaling laws in turbulence, viscoelasticity, particle transport in turbulence, microfluidics, nanofluidics, Direct Numerical Simulations, phase transition and nucleation problems, cavitation, wettability,  biological barriers permeabilization. 

Research activity and publications include molecular dynamics, free-energy and rare event methods, phase-field approaches for mesoscale modeling, fluctuating hydrodynamics, specialized numerical techniques, micro-fabrication, and design of microfluidic chips, also for biological and biomedical applications. The activity is strongly multidisciplinary, involving disciplines such as fluid mechanics, statistical mechanics, applied mathematics, experimental physics, fabrication technology, material science, biology, and medicine.

During these years the PI gained substantial experience in the field of High-Performance Computing, initially as an awardee of PRACE (Partnership for advanced computing in Europe) peer-reviewed computational grants for computational resources on Tier0 European HPC infrastructures, and successively as a member of the PRACE scientific committee and, quite recently, as a member of the EuroHPC Access Resource Committee. He has been consulted by the CINECA HPC infrastructure for the acquisition of pre-exascale machines.

In the 2013 call, the PI was awarded the prestigious ERC Advanced Grant for the project BIC (Cavitation across scales: following Bubble from Inception to Collapse, agreement # 339446–BIC), where multi-scale simulation techniques were conceived and developed to address the elusive problem of bubble nucleation addressed from the fundamental perspective of atomistic simulation to innovative mesoscale techniques. Besides direct application to cavitation, unexpected results dealt with nucleation in nanoscale confinement and intrusion extrusion mechanics in nanoporous materials. The results obtained in the BIC context received attention also from non-specialized media, with TV, radio, and newspaper interviews.

As a follow-up project BIC, the PI obtained funding from the ERC Proof-of-Concept (2017 call) for developing the INVICTUS (IN VItro Cavitation Through UltraSound, proposal  # 779751) platform for the study of cavitation enhanced endothelial permeability. The idea was to realize a standardized platform hosting a living and biologically functional endothelial layer to mimic a blood vessel on a chip, to understand the effect of ultrasound irradiated microbubbles in increasing the endothelial layer permeability in view of target drug delivery, and brain blood barrier opening.

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