Raffaele Strippoli

Pubblicazioni

Titolo Pubblicato in Anno
In vivo Bioluminescence-Based Monitoring of Liver Metastases from Colorectal Cancer: An Experimental Model JOURNAL OF MICROSCOPY AND ULTRASTRUCTURE 2019
Neutralization of IFN-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2018
ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer SCIENTIFIC REPORTS 2018
SMO inhibition modulates cellular plasticity and invasiveness in colorectal cancer FRONTIERS IN PHARMACOLOGY 2018
HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal OPEN ACCESS SCIENTIFIC REPORTS 2018
Role of the endocytosis of caveolae in intracellular signaling and metabolism Endocytosis and Signaling 2018
Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP CELL REPORTS 2018
Cell-based assays to study ERK pathway/caveolin1 interactions Methods in Molecular Biology 2017
Functional Roles and Therapeutic Applications of Exosomes in Hepatocellular Carcinoma BIOMED RESEARCH INTERNATIONAL 2017
Severe osteoarticular involvement in isotretinoin-triggered acne fulminans: two cases successfully treated with anakinra. JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 2017
In vivo bioluminescence-based monitoring of liver metastases from colorectal cancer: An experimental model JOURNAL OF MICROSCOPY AND ULTRASTRUCTURE 2017
Molecular Mechanisms Underlying Peritoneal EMT and Fibrosis STEM CELLS INTERNATIONAL 2016
TGFbeta induces binucleation/polyploidization in hepatocytes through a src-Dependent cytokinesis failure PLOS ONE 2016
Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis EMBO MOLECULAR MEDICINE 2015
Inhibition of natural killer cell cytotoxicity by interleukin-6: Implications for the pathogenesis of macrophage activation syndrome ARTHRITIS & RHEUMATOLOGY 2015
S100A12 as diagnostic tool in the differential diagnosis of sJIA associated MAS vs. hereditary or acquired HLH Pediatric Rheumatology online journalPEDIATRIC RHEUMATOLOGY ONLINE JOURNAL 2015
INHIBITION OF NATURAL KILLER (NK) CELL CYTOTOXICITY BY INTERLEUKIN-6: IMPLICATIONS FOR THE PATHOGENESIS OF MACROPHAGE ACTIVATION SYNDROME (MAS) PEDIATRIC BLOOD & CANCER 2015
Erratum to Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis [EMBO Mol Med (2015) 7: 102-123]. DOI 10.15252/emmm.201404127 EMBO MOLECULAR MEDICINE 2015

ERC

  • LS1_9
  • LS2_3
  • LS3
  • LS3_4
  • LS3_5
  • LS3_7
  • LS4_12
  • LS6
  • LS6_1
  • LS6_3

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

I have a background in innate immunity and in cellular/molecular biology. I am interested in molecular mechanisms controlling the induction/reversal of Epithelial to Mesenchymal Transition (EMT) and fibrosis. In particular, I focused my investigation in the role of both extracellular mediators and biomechanical/biophisical cues in the induction of cellular plasticity and signalling pathways implicated. I recently studied the interplay between Caveolin1, a plasma membrane mechanotransducer,  and YAP/TAZ, effectors of a main biomechanical pathway, in the induction of peritoneal fibrosis.

I am presently involved in research projects related to biomechanical regulation of EMT and to the control of EMT induction/reversal by epigenetic factors. Moreover, I am interested in the role of infections in the modulation of epithelial cell plasticity.

Keywords

cell signalling
Integrins
fibrosis mesothelial cells mechanotransduction YAP Caveolin1
Liver fibrosis
fibrosis
toll like receptors
Extracellular Signal-Regulated MAP Kinases
transforming growth factor beta (TGFβ)
epigenetics
HDAC inhibitors
biomechanics
pneumonia: Sars-Cov-2
Interleukin-6

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