Raffaele Strippoli

Pubblicazioni

Titolo Pubblicato in Anno
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2024
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2024
Immune checkpoints between epithelial-mesenchymal transition and autophagy: A conflicting triangle CANCER LETTERS 2024
Contribution of Autophagy to Epithelial Mesenchymal Transition Induction during Cancer Progression CANCERS 2024
Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Nanomedicine for autophagy modulation in cancer therapy: a clinical perspective CELL & BIOSCIENCE 2023
Geoffrey Cooper LA CELLULA 2023
Editorial: Autophagy modulation in cancer treatment utilizing nanomaterials and nanocarriers FRONTIERS IN ONCOLOGY 2023
POLY(I:C) INDUCES MORPHOLOGICAL CHANGES AND TYPE I INTERFERON-MEDIATED INFLAMMATORY RESPONSE IN MESOTHELIAL CELLS FROM PERITONEUM NEPHROLOGY DIALYSIS TRANSPLANTATION 2023
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress ANTIOXIDANTS 2023
Metal-based nanoparticles in cancer therapy: Exploring photodynamic therapy and its interplay with regulated cell death pathways INTERNATIONAL JOURNAL OF PHARMACEUTICS 2023
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2023
BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress ANTIOXIDANTS 2023
SYNCRIP Modulates the Epithelial-Mesenchymal Transition in Hepatocytes and HCC Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Exposure to b‐LED light while exerting antimicrobial activity on Gram‐negative and ‐positive bacteria promotes transient EMT‐like changes and growth arrest in keratinocytes INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells CELL DEATH & DISEASE 2022
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2022
Clinical Trials Involving Chemotherapy- Based Nanocarriers in Cancer Therapy: State of the Art and Future Directions Cancer Nanotechnology 2022
Ovarian cancer-driven mesothelial-to-mesenchymal transition is triggered by the endothelin-1/β-arr1 axis FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2021
Mechanisms of peritoneal fibrosis: focus on immune cells-peritoneal stroma interactions FRONTIERS IN IMMUNOLOGY 2021

ERC

  • LS1_9
  • LS2_3
  • LS3
  • LS3_4
  • LS3_5
  • LS3_7
  • LS4_12
  • LS6
  • LS6_1
  • LS6_3

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

I have a background in innate immunity and in cellular/molecular biology. I am interested in molecular mechanisms controlling the induction/reversal of Epithelial to Mesenchymal Transition (EMT) and fibrosis. In particular, I focused my investigation in the role of both extracellular mediators and biomechanical/biophisical cues in the induction of cellular plasticity and signalling pathways implicated. I recently studied the interplay between Caveolin1, a plasma membrane mechanotransducer,  and YAP/TAZ, effectors of a main biomechanical pathway, in the induction of peritoneal fibrosis.

I am presently involved in research projects related to biomechanical regulation of EMT and to the control of EMT induction/reversal by epigenetic factors. Moreover, I am interested in the role of infections in the modulation of epithelial cell plasticity.

Keywords

cell signalling
Integrins
fibrosis mesothelial cells mechanotransduction YAP Caveolin1
Liver fibrosis
fibrosis
toll like receptors
Extracellular Signal-Regulated MAP Kinases
transforming growth factor beta (TGFβ)
epigenetics
HDAC inhibitors
biomechanics
pneumonia: Sars-Cov-2
Interleukin-6

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