Ricerc@Sapienza

-Malattie Genetico-Metaboliche;
-Genetica del Diabete mellito tipo 2 e delle sue complicanze cardio e nefro-vascolari;
-Diabete monogenico;
-Genetica dell' insulino resistenza e dei suo correlati metabolici;
-Genetica dell'obesità monogenica e multifattoriale;
-Genetica della Sindrome Metabolica;
-Genetica ed Epigenetica del Diabete Gestazionale.

PROGETTI DI RICERCA (ultimi 5 anni)

-DIsentangling heterogeneIty aMong womEN with geStatIONal diAbetes meLlitus in iTalY (DIMENSIONALITY): a multi-centric prospective cohort study to improve the knowledge of gestational diabetes in Italy and the prediction and management of adverse cardiometabolic outcomes in mothers and offspring (SID-AMD);

-Towards a personalized precision medicine in rare disease: tirzepatide (a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist) monotherapy in patients with Wolfram syndrome type 1 (PNRR);

-Multi-omics analysis of pancreatic islet cells to unravel and validate new functional loci for beta cell targeted prediction, prevention and treatment of human type 2 diabetes (PRIN);

-Genetic and epigenetic studies to disentangle the disease heterogeneity in Italian patients with type 2 diabetes mellitus (Italian Ministry of Health);

-Intraclass safety and efficacy comparison among SGLT-2 inhibitors in elderly patients with type 2 diabetes. A pragmatic, phase IV, multicenter, open-label, randomised controlled trial. (GliflOzin in eLderly Diabetic patiENts: A praGmatic intraclass Evaluation trial: GOLDEN AGE) (AIFA);

-MicroRNAs as biomarkers of all-cause mortality and major acute cardiovascular events in patients with type 2 diabetes (Ateneo Sapienza)