Marialaura Petroni


Titolo Pubblicato in Anno
The Multiple Faces of the MRN Complex: Roles in Medulloblastoma and Beyond CANCERS 2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma CELL DEATH AND DIFFERENTIATION 2023
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma NEUROPATHOLOGY & APPLIED NEUROBIOLOGY 2022
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2 FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2021
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors ONCOGENE 2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module CELL REPORTS 2020
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i CANCERS 2020
Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer FRONTIERS IN ONCOLOGY 2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation CELL DEATH & DISEASE 2020
A novel BRCA2 splice variant identified in a young woman MOLECULAR GENETICS & GENOMIC MEDICINE 2020
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation INTERNATIONAL JOURNAL OF ONCOLOGY 2019
A simplified genomic profiling approach predicts outcome in metastatic colorectal cancer CANCERS 2019
Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer PEERJ 2019
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors SCIENTIFIC REPORTS 2019
Identification of novel BRCA1 large genomic rearrangements by a computational algorithm of amplicon-based Next-Generation Sequencing data PEERJ 2019
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis NATURE COMMUNICATIONS 2018
Effective treatment of a platinum-resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition MOLECULAR AND CLINICAL ONCOLOGY 2018
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors CELL DEATH & DISEASE 2018
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. SCIENTIFIC REPORTS 2017
PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma ONCOGENE 2017


  • LS1
  • LS1_9
  • LS3_6
  • LS4_12
  • LS5_3
  • LS5_11


  • Life-science technologies & biotechnologies

Interessi di ricerca

Studio del ruolo delle molecole della riposta al danno del DNA (DDR) nello sviluppo e nella cancerogenesi neuronale.






DNA damage response
primary cilium

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