Marco Pierini

Pubblicazioni

Titolo Pubblicato in Anno
Resorc[4]arene Modifiers for Supramolecular Site-Directed Immobilization of Antibodies on Multi-Walled Carbon Nanotubes CHEMBIOCHEM 2023
Insight into the photolytic degradation products of Rosuvastatin: Full chiral and structural elucidation and conversion kinetics by a combined chromatographic, spectroscopic and theoretical approach JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 2023
Evaluation of the Stereochemical Lability of Benzo-Cycloheptene-Based Drugs Endowed with Potentially Modulable Planar Chirality EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2023
Theoretically Predicted and Experimentally Detected Chirality of Dibenzocyclooctynes and Their Triazole Adducts with Azides JOURNAL OF ORGANIC CHEMISTRY 2023
Separation of monosaccharide anomers on photo-click cysteine-based stationary phase: the alpha/beta interconversion process studied by dynamic hydrophilic liquid chromatography SEPARATIONS 2022
From Macrocycles to Molecular Shuttles: Exploring the Supramolecular Assembly of Resorc[4]arenes. School of Physical Chemistry 2021 2021
Comparison of coated and immobilized chiral stationary phases based on amylose tris-[(S)-α-methylbenzylcarbamate] for the HPLC enantiomer separation of α-lipoic acid and its reduced form MOLECULES 2021
Chromatographic separation of the interconverting enantiomers of imidazo- and triazole-fused benzodiazepines JOURNAL OF CHROMATOGRAPHY A 2021
On-Column Quantification of Amino Functionalities Bonded to Solid Porous Matrices Packed within High Performance Liquid Chromatography Columns JOURNAL OF CHROMATOGRAPHY A 2021
PHANE-TetraPHOS, the First D2 Symmetric Chiral Tetraphosphane. Synthesis, Metal Complexation, and Application in Homogeneous Stereoselective Hydrogenation EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2021
Exploring the assembly of resorc[4]arenes for the construction of supramolecular nano-aggregates INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
High-performance liquid chromatography enantioseparation of chiral 2-(benzylsulfinyl)benzamide derivatives on cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase JOURNAL OF CHROMATOGRAPHY A 2020
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors JOURNAL OF MEDICINAL CHEMISTRY 2020
Phenyl(thio)phosphon(amid)ate benzenesulfonamides as potent and selective inhibitors of human carbonic anhydrases II and VII counteract allodynia in a mouse model of oxaliplatin-induced neuropathy JOURNAL OF MEDICINAL CHEMISTRY 2020
Site-directed antibodies immobilization by resorc[4]arene-based immunosensors CHEMISTRY-A EUROPEAN JOURNAL 2020
Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Chiral (cyclopentadienone)iron complexes with a stereogenic plane as pre-catalysts for the asymmetric hydrogenation of polar double bonds TETRAHEDRON 2019
Modular and conservative procedure for the quantification of amino functionalities bonded to solid porous matrices ANALYTICA CHIMICA ACTA 2019
TetraPh-Tol-BITIOPO: a new atropisomeric 3,3’-bithiophene based phosphine oxide as organocatalyst in Lewis Base-catalyzed Lewis Acid mediated reactions ORGANIC & BIOMOLECULAR CHEMISTRY 2019
An innovative method for quantification of basic sites linked on solid matrices Book of abstracts Merck Young Chemists’ Symposium XIX edition 2019

ERC

  • PE2_15
  • PE4_5
  • PE4_6
  • PE4_12
  • PE4_13
  • PE5_16
  • PE5_17
  • PE5_22
  • PE5_23

KET

  • Big data & computing

Interessi di ricerca

L’attività di ricerca è principalmente incentrata su studi di labilità stereochimica (processi di enantiomerizzazione e racemizzazione) e processi di interazione tra molecole (studi di Chimica Supramolecolare), condotti con l’ausilio di tecniche sia sperimentali (prevalentemente, cromatografia ad alte prestazioni in forma classica e dinamica, spettroscopia UV-visibile e NMR in forma classica e dinamica) che di calcolo computazionale (studi di docking molecolare; valutazione di barriere di attivazione di processi chimici, basata sul calcolo di stati di transizione; attribuzione della configurazione assoluta di molecole chirali in forma enantiopura, in molti casi rappresentate da farmaci o, più in generale, da molecole bioattive). In particolare, fenomeni di isomerizzazione stereochimica e costituzionale, e quando possibile decorsi di reazione, anche di tipo REDOX,  sono analizzati sotto il profilo termodinamico e cinetico, riservando speciale attenzione agli effetti prodotti in tal senso da variazioni di composizione del solvente di reazione (valutazioni basate sul ricorso ad approcci di tipo Linear Solvation Energy Relationships), della temperatura e, in solventi acquosi o acquoso-organici, del pH. Nell’interpretazione e razionalizzazione dei dati, lo studio sperimentale è integrato con l’uso di metodi di calcolo propri del molecular modelling, con la simulazione, quando necessario, di profili cromatografici dinamici e la determinazione di descrittori molecolari  (p.es. descrittori di acidità). 

Keywords

computational chemistry
dynamic chromatography
amino-groups dosage on silica
alkali-silica reaction
molecular docking simulation
Activation energies
stereochemistry
conformational analysis
chemical kinetics
Chiral Dynamic Chromatography
chiral molecular recognition
argentation chromatography
column liquid chromatography

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