Paolo Guglielmi | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2020
Natural compounds and extracts as novel antimicrobial agents	EXPERT OPINION ON THERAPEUTIC PATENTS	2020
Synthesis and biological evaluation of carvacrol-based derivatives as dual inhibitors of H. Pylori strains and ags cell proliferation	PHARMACEUTICALS	2020
Innovative pH-interfering agents in association with anticancer agents	pH-Interfering Agents as Chemosensitizers in Cancer Therapy	2020
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles	MOLECULES	2019
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2019
Novel therapies for glaucoma: a patent review (2013-2019)	EXPERT OPINION ON THERAPEUTIC PATENTS	2019
The up-regulation of oxidative stress as a potential mechanism of novel MAO-B inhibitors for glioblastoma treatment	MOLECULES	2019
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2019
Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2019
Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement?	EXPERT OPINION ON DRUG DISCOVERY	2019
Kinesin Eg5 targeting inhibitors as a new strategy for gastric adenocarcinoma treatment	MOLECULES	2019
Mechanisms of action of carbonic anhydrase inhibitors: compounds that bind “out of the binding site” and compounds with an unknown mechanism of action	Carbonic Anhydrases Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target	2019
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2018
Magnetic metal−organic framework composite by fast and facile mechanochemical process	INORGANIC CHEMISTRY	2018
Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2018
Enantiomers of triclabendazole sulfoxide: analytical and semipreparative HPLC separation, absolute configuration assignment, and transformation into sodium salt	JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS	2017
Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2017
Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2017
Protective effects Induced by microwave-assisted aqueous harpagophytum extract on rat cortex synaptosomes challenged with amyloid β-peptide	PHYTOTHERAPY RESEARCH	2017

ERC

PE5_18

KET

Advanced materials
Life-science technologies & biotechnologies

Interessi di ricerca

Design e sintesi di inibitori delle monoaminoossidasi umane (hMAO-A / hMAO-B).
Design e sintesi di inibitori selettivi delle isoforme IX e XII dell’anidrasi carbonica umana (hCA IX, hCA XII) implicate nei tumori.
Design e sintesi di farmaci antitumorali inibitori della chinesina Eg5.
Sviluppo e sintesi di metal-organic frameworks (MOFs) per applicazioni biomediche.

Ulteriori interessi di ricerca:

Impiego delle microonde nella sintesi chimica (molecole biologicamente attive, MOF) o per estrazioni di principi attivi da matrici vegetali (MAE).
Estrazione, purificazione e caratterizzazione di anticorpi monoclonali da matrici vegetali.

Progetti di Ricerca

Novel pyran-2-one based compounds for selective inhibition of tumor-related isoforms of human Carbonic Anhydrase hCA IX and XII. Synthesis, biological evaluation and docking studies.