Paolo Guglielmi

Pubblicazioni

Titolo Pubblicato in Anno
Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains of H. pylori and AGS Cell Line MOLECULES 2021
New aspects of monoamine oxidase b inhibitors: The key role of halogens to open the golden door CURRENT MEDICINAL CHEMISTRY 2021
High-performance liquid chromatography enantioseparation of chiral 2-(benzylsulfinyl)benzamide derivatives on cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase JOURNAL OF CHROMATOGRAPHY A 2020
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors JOURNAL OF MEDICINAL CHEMISTRY 2020
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Antimalarial Agents from Medicinal Plant and Fungal Sources Plant-derived Bioactives. Production, Properties and Therapeutic Applications 2020
Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2020
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2020
Natural compounds and extracts as novel antimicrobial agents EXPERT OPINION ON THERAPEUTIC PATENTS 2020
Synthesis and biological evaluation of carvacrol-based derivatives as dual inhibitors of H. Pylori strains and ags cell proliferation PHARMACEUTICALS 2020
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles MOLECULES 2019
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
Novel therapies for glaucoma: a patent review (2013-2019) EXPERT OPINION ON THERAPEUTIC PATENTS 2019
The up-regulation of oxidative stress as a potential mechanism of novel MAO-B inhibitors for glioblastoma treatment MOLECULES 2019
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement? EXPERT OPINION ON DRUG DISCOVERY 2019
Kinesin Eg5 targeting inhibitors as a new strategy for gastric adenocarcinoma treatment MOLECULES 2019
Mechanisms of action of carbonic anhydrase inhibitors: compounds that bind “out of the binding site” and compounds with an unknown mechanism of action Carbonic Anhydrases Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target 2019

ERC

  • PE5_18

KET

  • Advanced materials
  • Life-science technologies & biotechnologies

Interessi di ricerca

  • Design e sintesi di inibitori delle monoaminoossidasi umane (hMAO-A / hMAO-B).
  • Design e sintesi di inibitori selettivi delle isoforme IX e XII dell’anidrasi carbonica umana (hCA IX, hCA XII) implicate nei tumori.
  • Design e sintesi di farmaci antitumorali inibitori della chinesina Eg5.
  • Sviluppo e sintesi di metal-organic frameworks (MOFs) per applicazioni biomediche.

Ulteriori interessi di ricerca:

  • Impiego delle microonde nella sintesi chimica (molecole biologicamente attive, MOF) o per estrazioni di principi attivi da matrici vegetali (MAE).
  • Estrazione, purificazione e caratterizzazione di anticorpi monoclonali da matrici vegetali.

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