Angelo Toto | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains	THE JOURNAL OF BIOLOGICAL CHEMISTRY	2023
Different electrostatic forces drive the binding kinetics of SARS-CoV, SARS-CoV-2 and MERS-CoV Envelope proteins with the PDZ2 domain of ZO1	SCIENTIFIC REPORTS	2023
Targeting the Grb2 cSH3 domain: design, synthesis and biological evaluation of the first series of modulators	BIOORGANIC CHEMISTRY	2023
Monomeric and dimeric states of human ZO1-PDZ2 are functional partners of the SARS-CoV-2 E protein	COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL	2023
Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
An intramolecular energetic network regulates ligand recognition in a SH2 domain	PROTEIN SCIENCE	2023
Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands	ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS	2023
Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor	CANCERS	2022
On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains	BIOMOLECULES	2022
Characterization of early and late transition states of the folding pathway of a SH2 domain	PROTEIN SCIENCE	2022
Folding and binding mechanisms of the SH2 domain from Crkl	BIOMOLECULES	2022
Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat	PROTEIN SCIENCE	2022
Exploring the effect of tethered domains on the folding of Grb2 protein	ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS	2022
The cooperative folding of annexin A2 relies on a transient nonnative intermediate	BIOPHYSICAL JOURNAL	2022
SH2 Domains: Folding, Binding and Therapeutical Approaches	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Double mutant cycles as a tool to address folding, binding, and allostery	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
Folding and misfolding of a PDZ tandem repeat	JOURNAL OF MOLECULAR BIOLOGY	2021
Structural determinants driving the binding process between PDZ domain of wild type human PALS1 protein and SLiM sequences of SARS-CoV E proteins	COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL	2021
Probing the effects of local frustration in the folding of a multidomain protein	JOURNAL OF MOLECULAR BIOLOGY	2021
Determining folding and binding properties of the C-terminal SH2 domain of SHP2	PROTEIN SCIENCE	2021