Ricerc@Sapienza

For additional, informal information on my research interest, please visit the blog pages:

https://dariocolettithescientist.blogspot.com/

1. Pharmacological, physiological, and nutritional interventions against cachexia: My laboratory is focused on different approaches to counteract cancer cachexia, including pharmacological (exercise mimetics), physiological (physical activity), and nutritional (supplements) interventions in humans and animal models.
   
   1. Chiappalupi S et al. (2020) J Cachexia Sarcopenia Muscle;11(4):929-946. doi: 10.1002/jcsm.12561. Epub 2020 Mar 11. PMID: 32159297 xxx
   2. Baccam A, et al. (2019) Front Physiol;10:401. PMID: 31068826
   3. Garcia M, et al. (2019) VNutrition; 60:66-69. PMID: 30529188
   4. Pigna E, et al. (2016) Sci Rep; 6:26991. PMID: 27244599
   5. Carotenuto F, et al.(2016)  Int J Med Sci;13(3):206-19. PMID: 26941581          

2. Patents and technology transfer: I am co-inventor of a patented procedure to produce Hsp60-enriched exosomes with exercise-mimetic activity, a product that is, therefore, called Physiactisome. Patent: Physiactisome – «Procedure for the synthesis of HSP-containing exosomes and their use against muscle atrophy and cachexia» - patent n. 102018000009235 on 8/10/2018, deposited by Università di Palermo. Owners: Università di Palermo, Università di Roma La Sapienza, Nanovector Torino, Sorbonne Université. List of inventors: Valentina Di Felice, et al. International publication number WO 2020/075004 A1. This product can be exploited against muscle atrophy, since it ameliorates muscle endurance and homeostasis. The presentation of the product and the corresponding Spinoff project (iBioTHEx) was awarded the third prize (5000 Euro) at the EIT JumpStarter Grand final, Health category, Riga, Latvia, 15-17/11/2019

   1. Barone R, et al.(2016) Sci Rep; 6:19781. PMID: 26812922
3. Pathophysiology of muscle tissues: I contribute to discovering and explaining those mechanisms underlying pathologies of the striated and smooth muscle tissues; this activity is carried out at Sorbonne University by using genetic murine models.
4. 1. Tannous C, et al. (2021) Int J Mol Sci;22(7):3534. PMID: 33805532
   2. Langlois B, (2017) Sci Rep; 7(1):11628. PMID: 28912461
   3. Galmiche G, (2013) Circ Res;112(7):1035-45, 2013