Antonio Coluccia


Titolo Pubblicato in Anno
New inhibitors of indoleamine 2,3-dioxygenase 1: molecular modeling studies, synthesis, and biological evaluation JOURNAL OF MEDICINAL CHEMISTRY 2016
Structure-based virtual screening to get new scaffold inhibitors of the Ser/Thr protein kinase PknB from Mycobacterium tuberculosis LETTERS IN DRUG DESIGN & DISCOVERY 2016
New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents JOURNAL OF MEDICINAL CHEMISTRY 2015
Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors JOURNAL OF MEDICINAL CHEMISTRY 2015
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer JOURNAL OF MEDICINAL CHEMISTRY 2015
Poster: "In vivo selection of JARID histone demethylases inhibitors and their use to enlighten the biological role of these enzymes in yeast and mammalian cells with focus on transcriptional regulation” Abstracts of the 27th International Conference on Yeast Genetics and Molecular Biology 2015
New indole tubulin assembly inhibitors with stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer SIMCC2015 2015
Synthesis of New Indoles with Potent Tubulin Polymerization Inhibiting Activity Including Hedgehog-Dependent Cancer and Enhanced Stimulation of NK Cell Cytotoxic Activity Abstract eBook 2015
Drug Design and Synthesis of New Indolylarylsulfones as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors Abstract eBook 2015
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses VIROLOGY JOURNAL 2015


  • PE5_18


  • Life-science technologies & biotechnologies

Interessi di ricerca

The focus of my research is in the application of computer-based methods to speed up the discovery of novel small molecules endowed with promising biological activity. The chemoinformatic approaches moves from classical to more advanced molecular modeling techniques. The research activity include the hit-compounds identification, mainly by virtual screening as well as the hit-to-lead process by re-branching, docking and molecular dynamics.

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