Antonio Coluccia

Pubblicazioni

Titolo Pubblicato in Anno
Anticancer activity of (S)-5-Chloro-3-((3,5-dimethylphenyl)sulfonyl)-N-(1-oxo-1-((pyridin-4-ylmethyl)amino)propan-2-yl)-1H-indole-2-carboxamide (RS4690), a new dishevelled 1 inhibitor CANCERS 2022
Exploring CCRL2 chemerin binding using accelerated molecular dynamics PROTEINS 2022
Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer BIOLOGY DIRECT 2021
Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Discovery of Zika virus NS2B/NS3 inhibitors that prevent mice from fife-threatening infection and brain damage ACS MEDICINAL CHEMISTRY LETTERS 2020
New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Enzymatic kinetic resolution of desmethylphosphinothricin indicates that phosphinic group is a bioisostere of carboxyl group COMMUNICATIONS CHEMISTRY 2020
Modeling Epac1 interactions with the allosteric inhibitor AM-001 by co-solvent molecular dynamics JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 2020
Sulfonamide inhibitors of beta-Catenin signaling as anticancerAgents with different output on c-Myc CHEMMEDCHEM 2020
Mutational analysis of the essential lipopolysaccharide-transport protein LptH of Pseudomonas aeruginosa to uncover critical oligomerization sites SCIENTIFIC REPORTS 2020
Targeting the interaction between the SH3 domain of Grb2 and Gab2 CELLS 2020
Drug design and synthesis of first in class PDZ1 targeting NHERF1 inhibitors as anticancer agents ACS MEDICINAL CHEMISTRY LETTERS 2019
Towards modern anticancer agents that interact with tubulin EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 2019
Nox2-mediated platelet activation by glycoprotein (GP) VI: Effect of rivaroxaban alone and in combination with aspirin BIOCHEMICAL PHARMACOLOGY 2019
Small molecule inhibitors of KDM5 histone demethylases increase the radiosensitivity of breast cancer cells overexpressing Jarid1b MOLECULES 2019
Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
Identification of a pharmacological inhibitor of Epac1 that protects the heart against acute and chronic models of cardiac stress CARDIOVASCULAR RESEARCH 2019
β-catenin knockdown promotes nherf1-mediated survival of colorectal cancer cells: implications for a double-targeted therapy ONCOGENE 2018
New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018

ERC

  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

The focus of my research is in the application of computer-based methods to speed up the discovery of novel small molecules endowed with promising biological activity. The chemoinformatic approaches moves from classical to more advanced molecular modeling techniques. The research activity include the hit-compounds identification, mainly by virtual screening as well as the hit-to-lead process by re-branching, docking and molecular dynamics.

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