Alessandro Fatica


Titolo Pubblicato in Anno
METTL3 regulates WTAP protein homeostasis CELL DEATH & DISEASE 2018
N6-Methyladenosine Role in Acute Myeloid Leukaemia INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018
Argonaute 2 drives miR-145-dependent gene expression program influencing epithelial to mesenchymal transition in breast cancer cells Italian Journal od Anatomy and EmbryologyITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY 2018
A positive feed-forward regulatory loop between METTL3 and WTAP sustains the oncogenic role of the m6A methylation complex in myeloid leukemia Programme & Abstracts Book 2018
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis MOLECULAR CELL 2017
Effect of miR-204&211 and RUNX2 control on the fate of human mesenchymal stromal cells REGENERATIVE MEDICINE RESEARCH 2017
Non-coding RNAs in muscle differentiation and musculoskeletal disease THE JOURNAL OF CLINICAL INVESTIGATION 2016
The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA ONCOTARGET 2016
Unraveling the function of m6A modification in acute myeloid leukemia Programme and Abstracts XIV FISV Congress 2016
Long Non-Coding RNAs: New Players in Hematopoiesis and Leukemia FRONTIERS IN MEDICINE 2015
C/EBPα-p30 protein induces expression of the oncogenic long non-coding RNA UCA1 in acute myeloid leukemia ONCOTARGET 2015
Circulating Noncoding RNAs as Clinical Biomarkers Epigenetic Biomarkers and Diagnostics 2015


  • LS1
  • LS1_3


  • Life-science technologies & biotechnologies

Interessi di ricerca

Recent studies have uncovered an important role for RNA modifications in gene expression regulation, which led to the birth of the epitranscriptomics field. It is now acknowledged that RNA modifiers play a crucial role in the control of differentiation of stem and progenitor cells and that changes in their levels are a relevant feature of different types of cancer. One of most studied RNA modifications with a well-define role in gene expression regulation is the N6-methyladenosine (m6A), which is the more abundant internal modification in mRNA, regulating the expression of the latter at different levels, from maturation to translation. Our lab is involved in understanding the cellular processes it regulates, its mechanism of action and its involvement in leukemia.  In particular, our aim is to identify a) the RNA targets (coding and non-coding) of this modification with a potential role in leukemia; and b) specific regulatory proteins of the METTL3 complex in leukemia cells.


acute myeloid leukemia
RNA modifications

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma