Alessandro Fatica

Pubblicazioni

Titolo Pubblicato in Anno
circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer GENES, CHROMOSOMES & CANCER 2023
Regulation of gene expression by m6Am RNA modification INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation CANCER LETTERS 2023
The Emerging Role of RNA in Diseases and Cancers INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3 CANCER COMMUNICATIONS 2023
Long Non-Coding RNAs in the Cell Fate Determination of Neoplastic Thymic Epithelial Cells FRONTIERS IN IMMUNOLOGY 2022
MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer COMMUNICATIONS BIOLOGY 2022
Multiple roles of m6A RNA modification in translational regulation in cancer INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism GENOME BIOLOGY 2021
Regulation of ribosome function by RNA modifications in hematopoietic development and leukemia: it is not only a matter of m6A INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function ELIFE 2021
METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors CLINICAL EPIGENETICS 2021
New insight into the catalytic -dependent and -independent roles of METTL3 in sustaining aberrant translation in chronic myeloid leukemia CELL DEATH & DISEASE 2021
Modulation of circRNA Metabolism by m6A Modification CELL REPORTS 2020
LINC00174 is a novel prognostic factor in thymic epithelial tumors involved in cell migration and lipid metabolism CELL DEATH & DISEASE 2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation CELL DEATH & DISEASE 2020
Argonaute 2 drives miR-145-5p-dependent gene expression program in breast cancer cells CELL DEATH & DISEASE 2019
The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism NUCLEIC ACIDS RESEARCH 2019
N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia FRONTIERS IN ONCOLOGY 2019
Interplay between N6-methyladenosine (m6A) and non-coding RNAs in cell development and cancer FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 2019

ERC

  • LS1
  • LS1_3

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Recent studies have uncovered an important role for RNA modifications in gene expression regulation, which led to the birth of the epitranscriptomics field. It is now acknowledged that RNA modifiers play a crucial role in the control of differentiation of stem and progenitor cells and that changes in their levels are a relevant feature of different types of cancer. One of most studied RNA modifications with a well-define role in gene expression regulation is the N6-methyladenosine (m6A), which is the more abundant internal modification in mRNA, regulating the expression of the latter at different levels, from maturation to translation. Our lab is involved in understanding the cellular processes it regulates, its mechanism of action and its involvement in leukemia.  In particular, our aim is to identify a) the RNA targets (coding and non-coding) of this modification with a potential role in leukemia; and b) specific regulatory proteins of the METTL3 complex in leukemia cells.

Keywords

m6A
acute myeloid leukemia
RNA modifications

Laboratori di ricerca

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