Ricerc@Sapienza

Research Focus

• Translational Medicine with emphasis on oncology (targeted therapies) and regenerative medicine (adult stem cells)

• Studies on the biological effects of nano/microplastics on human cells

Oncology Research

• Expertise in rhabdomyosarcoma and ovarian cancer

• Study of epigenetic regulators and microRNAs in tumor initiation, progression and therapy resistance

• Identification of novel therapeutic targets and combinatorial treatment strategies

• First to demonstrate DNMT3B overexpression in rhabdomyosarcoma and its role in tumor growth, motility, and metastasis

Regenerative Medicine

• Bone regeneration using adipose-derived stem cells (ASCs) and biomimetic scaffolds

• Enhancement of osteogenic differentiation through epigenetic modulation and bioactive compounds

• Development of advanced tissue-engineering strategies bridging basic science and clinical application

Technologies & Expertise

• Next-Generation Sequencing, Digital PCR, Nanostring nCounter

• Extensive experience with mammalian cell culture, including primary cells and adult stem cells

• 3D cell culture, organoids and BIOX6 3D bioprinting for modeling tumor biology and microenvironments

Recent Research Directions

• 3D bioprinted tumor and stromal models for functional studies

• ASC-based approaches for osteogenic regeneration and myocardial infarction