Paolo Guglielmi | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Chiral Hydroxy Metabolite of Mebendazole: Analytical and Semi-Preparative High-Performance Liquid Chromatography Resolution and Chiroptical Properties	PHARMACEUTICALS	2024
Novel Insights on CAI–CORM Hybrids: Evaluation of the CO Releasing Properties and Pain-Relieving Activity of Differently Substituted Coumarins for the Treatment of Rheumatoid Arthritis	JOURNAL OF MEDICINAL CHEMISTRY	2023
Indoleamine 2,3-dioxygenase	Metalloenzymes: from bench to bedside	2023
Kinetic Study on the Base-Catalyzed Imine-Enamine Tautomerism of a Chiral Biologically Active Isoxazoline Derivative by HPLC on Amylose Tris(3,5-dimethylphenylcarbamate) Chiral Stationary Phase	MOLECULES	2023
Novel therapeutic opportunities for Toxoplasma gondii, Trichomonas vaginalis, and Giardia intestinalis infections	EXPERT OPINION ON THERAPEUTIC PATENTS	2023
A Multitarget Approach against Neuroinflammation: Alkyl Substituted Coumarins as Inhibitors of Enzymes Involved in Neurodegeneration	ANTIOXIDANTS	2023
Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Metal-organic frameworks (MOFs) as biomolecules drug delivery systems for anticancer purposes	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2022
Treatment of Toxoplasmosis: An Insight on Epigenetic Drugs	Topics in Medicinal Chemistry	2022
An updated patent review on monoamine oxidase (MAO) inhibitors	EXPERT OPINION ON THERAPEUTIC PATENTS	2022
Aurone Scaffold and Structural Analogues for the Development of Monoamine Oxidase (MAO) Inhibitors	Flavonoids and Phenolics	2022
Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains of H. pylori and AGS Cell Line	MOLECULES	2021
Dual carbonic anhydrase ix/xii inhibitors and carbon monoxide releasing molecules modulate LPS-mediated inflammation in mouse macrophages	ANTIOXIDANTS	2021
New aspects of monoamine oxidase b inhibitors: The key role of halogens to open the golden door	CURRENT MEDICINAL CHEMISTRY	2021
An innovative spectroscopic approach for qualitative and quantitative evaluation of Mb-CO from myoglobin carbonylation reaction through chemometrics methods	SPECTROCHIMICA ACTA. PART A, MOLECULAR AND BIOMOLECULAR SPECTROSCOPY	2021
High-performance liquid chromatography enantioseparation of chiral 2-(benzylsulfinyl)benzamide derivatives on cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase	JOURNAL OF CHROMATOGRAPHY A	2020
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors	JOURNAL OF MEDICINAL CHEMISTRY	2020
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2020
Antimalarial Agents from Medicinal Plant and Fungal Sources	Plant-derived Bioactives. Production, Properties and Therapeutic Applications	2020
Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2020

ERC

PE5_18

KET

Advanced materials
Life-science technologies & biotechnologies

Interessi di ricerca

Design e sintesi di inibitori delle monoaminoossidasi umane (hMAO-A / hMAO-B).
Design e sintesi di inibitori selettivi delle isoforme IX e XII dell’anidrasi carbonica umana (hCA IX, hCA XII) implicate nei tumori.
Design e sintesi di farmaci antitumorali inibitori della chinesina Eg5.
Sviluppo e sintesi di metal-organic frameworks (MOFs) per applicazioni biomediche.

Ulteriori interessi di ricerca:

Impiego delle microonde nella sintesi chimica (molecole biologicamente attive, MOF) o per estrazioni di principi attivi da matrici vegetali (MAE).
Estrazione, purificazione e caratterizzazione di anticorpi monoclonali da matrici vegetali.

Progetti di Ricerca

Novel pyran-2-one based compounds for selective inhibition of tumor-related isoforms of human Carbonic Anhydrase hCA IX and XII. Synthesis, biological evaluation and docking studies.