Daniela Secci

Pubblicazioni

Titolo Pubblicato in Anno
3-(Phenyl-4-oxy)-5-phenyl-4,5-dihydro-(1H)-pyrazole: a fascinating molecular framework to study the enantioseparation ability of the amylose (3,5-dimethylphenylcarbamate) chiral stationary phase. Part II. Solvophobic effects in enantiorecognition process JOURNAL OF CHROMATOGRAPHY A 2017
Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
Synthesis, biological evaluation and quantitative structure-active relationships of 1,3-thiazolidin-4-one derivatives. A promising chemical scaffold endowed with high antifungal potency and low cytotoxicity EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2017
Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
Protective effects Induced by microwave-assisted aqueous harpagophytum extract on rat cortex synaptosomes challenged with amyloid β-peptide PHYTOTHERAPY RESEARCH 2017
Optimization of aqueous extraction and biological activity of harpagophytum procumbens root on ex vivo rat Colon inflammatory model PHYTOTHERAPY RESEARCH 2017
Neem oil nanoemulsions: characterisation and antioxidant activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms BIOORGANIC & MEDICINAL CHEMISTRY 2016
Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2016
Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells ONCOTARGET 2016
3-(Phenyl-4-oxy)-5-phenyl-4,5-dihydro-(1H)-pyrazole: a fascinating molecular framework to study the enantioseparation ability of the amylose (3,5-dimethylphenylcarbamate) chiral stationary phase. Part I. Structure-enantioselectivity relationships JOURNAL OF CHROMATOGRAPHY A 2016
Elucidation of the mechanisms governing the thermal diastereomerization of bioactive chiral 1,3,4-thiadiazoline spiro-cyclohexyl derivatives towards their anancomeric stereoisomers RSC ADVANCES 2016
Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2016
Identification of new anti-Candida compounds by ligand-based pharmacophore virtual screening JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2016
Out of the active site binding pocket for carbonic anhydrase inhibitors CHEMICAL COMMUNICATIONS 2015
The anancomeric character of the pharmacophore 1,3,4-thiadiazoline framework in chiral spiro-cyclohexyl derivatives: effects on stereochemistry and spiro-junction lability. Thermodynamic aspects JOURNAL OF ORGANIC CHEMISTRY 2015
Synthesis and pharmacological screening of a large library of 1,3,4-thiadiazolines as innovative therapeutic tools for the treatment of prostate cancer and melanoma EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015
Optimization of the microwave-assisted extraction of Azadirachta indica (Neem) leaves Using NMR-based metabolic fingerprinting CURRENT BIOACTIVE COMPOUNDS 2015

ERC

  • LS1_13
  • PE5_17
  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

  1. Progettazione, sintesi e valutazione biologica di nuovi inibitori selettivi sulle mono ammino ossidasi, MAO-A e MAO-B,
  2. Progettazione, sintesi e valutazione biologica di nuovi modulatori epigenetici con particolare riferimento agli inibitori dell’acetiltransferasi (HATs) ad attività apoptotica e citodifferenziante
  3. Progettazione, sintesi e valutazione biologica di nuovi inibitori selettivi delle isoforme IX e XII dell’anidrasi carbonica per il trattamento di patologie tumorali
  4. Sviluppo e la caratterizzazione di anticorpi monoclonali biosimilari per uso terapeutico isolati da piante transgeniche
  5. Sviluppo e sintesi di metal-organic frameworks (MOFs) per applicazioni biomediche.

Keywords

drug design and discovery
Anticancer agents
neuroprotective agents
Anti-Infective Agents

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