Daniela Secci


Titolo Pubblicato in Anno
Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Synthesis and Evaluation of Thymol-Based Synthetic Derivatives as Dual-Action Inhibitors against Different Strains of H. pylori and AGS Cell Line MOLECULES 2021
High-performance liquid chromatography enantioseparation of chiral 2-(benzylsulfinyl)benzamide derivatives on cellulose tris(3,5-dichlorophenylcarbamate) chiral stationary phase JOURNAL OF CHROMATOGRAPHY A 2020
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors JOURNAL OF MEDICINAL CHEMISTRY 2020
Metabolic profiling of different wild and cultivated Allium species based on high-resolution mass spectrometry, high-performance liquid chromatography-photodiode array detector, and color analysis JOURNAL OF MASS SPECTROMETRY 2020
Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2020
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
Antimalarial Agents from Medicinal Plant and Fungal Sources Plant-derived Bioactives. Production, Properties and Therapeutic Applications 2020
Synthesis and evaluation of a large library of nitroxoline derivatives as pancreatic cancer antiproliferative agents JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2020
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2020
Synthesis and biological evaluation of carvacrol-based derivatives as dual inhibitors of H. Pylori strains and ags cell proliferation PHARMACEUTICALS 2020
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles MOLECULES 2019
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
Novel approaches to the discovery of selective human monoamine oxidase-B inhibitors: is there room for improvement? EXPERT OPINION ON DRUG DISCOVERY 2019
Investigation on the stability of new biologically active thiosemicarbazone-derived compounds by a validated HPLC-PDA method CURRENT ANALYTICAL CHEMISTRY 2019
Bioactive isoflavones from Pueraria lobata root and starch: Different extraction techniques and carbonic anhydrase inhibition FOOD AND CHEMICAL TOXICOLOGY 2018
A chromatographic study on the exceptional chiral recognition of 2-(benzylsulfinyl)benzamide by animmobilized-type chiral stationary phase based on cellulose tris(3,5-dichlorophenylcarbamate) JOURNAL OF CHROMATOGRAPHY A 2018
Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2018


  • LS1_13
  • PE5_17
  • PE5_18


  • Life-science technologies & biotechnologies

Interessi di ricerca

  1. Progettazione, sintesi e valutazione biologica di nuovi inibitori selettivi sulle mono ammino ossidasi, MAO-A e MAO-B,
  2. Progettazione, sintesi e valutazione biologica di nuovi modulatori epigenetici con particolare riferimento agli inibitori dell’acetiltransferasi (HATs) ad attività apoptotica e citodifferenziante
  3. Progettazione, sintesi e valutazione biologica di nuovi inibitori selettivi delle isoforme IX e XII dell’anidrasi carbonica per il trattamento di patologie tumorali
  4. Sviluppo e la caratterizzazione di anticorpi monoclonali biosimilari per uso terapeutico isolati da piante transgeniche
  5. Sviluppo e sintesi di metal-organic frameworks (MOFs) per applicazioni biomediche.


drug design and discovery
Anticancer agents
neuroprotective agents
Anti-Infective Agents

Laboratori di ricerca

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