Roberta Chiaraluce | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Critical assessment of genome interpretation consortium. CAGI, the critical assessment of genome interpretation, establishes progress and pprospects for computational genetic variant interpretation methods.	GENOME BIOLOGY	2024
The role of Zn ions in the interaction between SARS-CoV-2 orf7a protein and BST2/tetherin	THE EUROPEAN PHYSICAL JOURNAL PLUS	2023
Interpretation of missense variants found in association with cancer	Encyclopedia of life science	2023
Mutation in the common docking domain affects MAP kinase ERK2 catalysis and stability	CANCERS	2023
The complex impact of cancer‑related missense mutations on the stability and on the biophysical and biochemical properties of MAPK1 and MAPK3 somatic variants	HUMAN GENOMICS	2023
Metal ion binding in wild-type and mutated frataxin: a stability study	FRONTIERS IN MOLECULAR BIOSCIENCES	2022
Analysis and interpretation of the impact of missense variants in cancer	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
A glimpse into the structural properties of the intermediate and transition state in the folding of bromodomain 2 d2 by Φ value analysis	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
Fondamenti di biochimica umana	Fondamenti di biochimica umana	2021
Zn-induced interactions between SARS-CoV-2 orf7a and BST2/Tetherin	CHEMISTRYOPEN	2021
Characterization of human frataxin missense variants in cancer tissues	HUMAN MUTATION	2019
Evaluating the predictions of the protein stability change upon single amino acid substitutions for the FXN CAGI5 challenge	HUMAN MUTATION	2019
Dealing with Cu reduction in X-ray absorption spectroscopy experiments	METALLOMICS	2019
The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme	PLOS ONE	2018
PEGylated β-sheet breaker peptides as Inhibitors of β-amyloidf ibrillization	CHEMPLUSCHEM	2017
Single-Nucleotide polymorphism of PPARγ, a protein at the crossroads of physiological and pathological processes	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2017
The effect of β-sheet breaker peptides on metal associated Amyloid-β peptide aggregation process	BIOPHYSICAL CHEMISTRY	2017
Unveiling the folding mechanism of the bromodomains	BIOCHEMISTRY AND BIOPHYSICS REPORTS	2017
Production of functional, stable, unmutated recombinant human papillomavirus E6 oncoprotein: implications for HPV-tumor diagnosis and therapy	JOURNAL OF TRANSLATIONAL MEDICINE	2016
Effect of bet missense mutations on bromodomain function, inhibitor binding and stability	PLOS ONE	2016

ERC

LS1_2
LS1_4
LS1_11

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Protein stability, Protein structure and function. Protein variants and disease.

Keywords

protein stability

missense variants

Progetti di Ricerca

Erk1 and cancer. Are this protein and its natural variants a special hotspot for mutations?
The human frataxin variants found in carcinoma cells display different functional activity and conformational stability compared to the wild type enzyme.