| Titolo |
Pubblicato in |
Anno |
| Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase |
PROTEIN SCIENCE |
2024 |
| Fragment merging, growing, and linking identify new trypanothione reductase inhibitors for Leishmaniasis |
JOURNAL OF MEDICINAL CHEMISTRY |
2024 |
| Sorcin in Cancer Development and Chemotherapeutic Drug Resistance |
CANCERS |
2024 |
| AI is a viable alternative to high throughput screening: a 318-target study |
SCIENTIFIC REPORTS |
2024 |
| The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target |
THE FEBS JOURNAL |
2024 |
| Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
2023 |
| Optimization of Potent and Specific Trypanothione Reductase Inhibitors: A Structure-Based Drug Discovery Approach |
ACS INFECTIOUS DISEASES |
2022 |
| Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design |
FRONTIERS IN MOLECULAR BIOSCIENCES |
2022 |
| Known drugs identified by structure-based virtual screening are able to bind sigma-1 receptor and increase growth of huntington disease patient-derived cells |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES |
2021 |
| Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase |
THE JOURNAL OF BIOLOGICAL CHEMISTRY |
2021 |
| Structure and metal-binding properties of PA4063, a novel player in periplasmic zinc trafficking by Pseudomonas aeruginosa |
ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY |
2021 |
| Huntingtin ubiquitination mechanisms and novel possible therapies to decrease the toxic effects of mutated huntingtin |
JOURNAL OF PERSONALIZED MEDICINE |
2021 |
| Re-discovery of giardiavirus: Genomic and functional analysis of viruses from giardia duodenalis isolates |
BIOMEDICINES |
2021 |
| Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases |
CELL DEATH & DISEASE |
2020 |
| Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome |
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS |
2020 |
| Roles of sorcin in drug resistance in cancer: one protein, many mechanisms, for a novel potential anticancer drug target |
CANCERS |
2020 |
| Targeting trypanothione reductase, a key enzyme in the redox trypanosomatid metabolism, to develop new drugs against leishmaniasis and trypanosomiases |
MOLECULES |
2020 |
| Spiro-containing derivatives show antiparasitic activity against trypanosoma brucei through inhibition of the trypanothione reductase enzyme |
PLOS NEGLECTED TROPICAL DISEASES |
2020 |
| Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism |
AMINO ACIDS |
2019 |
| Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases |
FRONTIERS IN BIOSCIENCE |
2018 |
