Annarita Fiorillo


Titolo Pubblicato in Anno
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase PROTEIN SCIENCE 2024
Fragment merging, growing, and linking identify new trypanothione reductase inhibitors for Leishmaniasis JOURNAL OF MEDICINAL CHEMISTRY 2024
Investigation of the Entry Pathway and Molecular Nature of σ1 Receptor Ligands INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Optimization of Potent and Specific Trypanothione Reductase Inhibitors: A Structure-Based Drug Discovery Approach ACS INFECTIOUS DISEASES 2022
Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design FRONTIERS IN MOLECULAR BIOSCIENCES 2022
Known drugs identified by structure-based virtual screening are able to bind sigma-1 receptor and increase growth of huntington disease patient-derived cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021
Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase THE JOURNAL OF BIOLOGICAL CHEMISTRY 2021
Structure and metal-binding properties of PA4063, a novel player in periplasmic zinc trafficking by Pseudomonas aeruginosa ACTA CRYSTALLOGRAPHICA. SECTION D, STRUCTURAL BIOLOGY 2021
Huntingtin ubiquitination mechanisms and novel possible therapies to decrease the toxic effects of mutated huntingtin JOURNAL OF PERSONALIZED MEDICINE 2021
Re-discovery of giardiavirus: Genomic and functional analysis of viruses from giardia duodenalis isolates BIOMEDICINES 2021
Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases CELL DEATH & DISEASE 2020
Profiling calcium-dependent interactions between Sorcin and intrinsically disordered regions of human proteome BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 2020
Roles of sorcin in drug resistance in cancer: one protein, many mechanisms, for a novel potential anticancer drug target CANCERS 2020
Targeting trypanothione reductase, a key enzyme in the redox trypanosomatid metabolism, to develop new drugs against leishmaniasis and trypanosomiases MOLECULES 2020
Spiro-containing derivatives show antiparasitic activity against trypanosoma brucei through inhibition of the trypanothione reductase enzyme PLOS NEGLECTED TROPICAL DISEASES 2020
Structure-guided approach to identify a novel class of anti-leishmaniasis diaryl sulfide compounds targeting the trypanothione metabolism AMINO ACIDS 2019
Metal- and metalloid-containing drugs for the treatment of trypanosomatid diseases FRONTIERS IN BIOSCIENCE 2018
Study of manganese binding to the ferroxidase centre of human H-type ferritin JOURNAL OF INORGANIC BIOCHEMISTRY 2018
The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme PLOS ONE 2018
Toward a Drug Against All Kinetoplastids: From LeishBox to Specific and Potent Trypanothione Reductase Inhibitors MOLECULAR PHARMACEUTICS 2018

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