Ricerc@Sapienza

The early research conducted by Antonelli was focused on elucidating the in vivo and in vitro mechanisms regulating the production and activity of interferons during viral infections. His research group currently investigates the role of innate immunity, as well as the pathogenesis, diagnosis, and control of several viral infections, including HIV, HCV, major respiratory viruses (such as SARS-CoV-2, RSV, and influenza viruses), and HPV. In recent years, the group is particularly focusing on identifying: the determinants of disease severity associated with respiratory virus infections, employing integrated in vitro, ex vivo, and in vivo experimental approaches; predictive and surrogate markers of viral reactivation in specific clinical contexts (e.g., immunocompromised patients), as well as biomarkers of the immune response to vaccination against viral pathogens. More recently, Antonelli’s research interests have broadened to encompass microbiological issues such as the pathogenesis and management of nosocomial infections, and antimicrobial resistance.
He has been, and continues to be, actively involved in numerous national and international research projects, primarily addressing HIV, SARS-CoV-2, and antimicrobial resistance.