Ricerc@Sapienza

The reciprocal interplay between the circadian clock machinery and hypothalamus-pituitary-adrenal axis has been largely demonstrated: the circadian clock may control the physiological circadian endogenous glucocorticoid (GC) secretion and action; GCs, in turn, are potent regulators of the circadian clock and their inappropriate replacement has been associated with metabolic and immune impairment. The aim of our research was to investigate the interaction between the timing-of-the-day exposure to different GC’s concentrations and metabolic or immune functions. Some metabolic diseases as Cushing Sindrome (CS) and Adrenal insufficiency (AI) requires lifelong glucocorticoid (GC) replacement.