Ricerc@Sapienza

IL TUMORE, REINTRA NELLE MALATTIE AMBIENTALI, NON TRASMISSIBILI, INFATTI UNA PLETORA DI DATI IN LETTERATURA SCIENTIFICA, CORRELANO L'INSORGENZA DELLE PATOLOGIE TUMORALI CON L'AMBIENTE IN PARTICOLALE CON GLI INQUINANTI AMBIENTALI, TANTO DA DEFINIFIRE IL PROCESSO DI SVILUPPO DEL TUMORE COME CARCINOGENSI CHIMICA.

The Leishmaniasis: Structural Biology and Drug Discovery Group is a joint collaboration between Sapienza University of Rome and CNR–IBPM. (Members: Annarita Fiorillo (Sapienza University of Rome), Andrea Ilari (CNR-IBPM), Gianni Colotti (CNR-IBPM))

Conseguenze della produzione delle specie reattive dell'ossigeno sulla struttura e sulla funzione delle proteine e studio del ruolo biologico delle ammino ossidasi nel metabolismo delle amine biogene e nella produzione del perossido di idrogeno e delle aldeidi. 

Our research group is interested in the regulation of VitaminB6 metabolism in bacteria and humans, and in diseases caused by Vitamin B6 malfunctioning.

Specifically, our studies focus on:

i) Transcriptional regulation of Vitamin $\text{B}_6$ metabolism in bacteria;

ii) Allosteric properties of proteins involved in Vitamin $\text{B}_6$ metabolism in bacteria and humans;

iii) Molecular basis of neurological diseases caused by defects in Vitamin $\text{B}_6$ metabolism;

The Lab is runed by 3 peers: Carlo Travaglini Allocatelli, Giorgio Giardina and Adele Di Matteo

WHAT: The Lab is focused on the determination of 3D protein structures at the atomic level and on the analysis of protein folding and miss-folding process including beta-amyloid formation. 

Cell growth is regulated by coordination of both extracellular nutrients and intracellular metabolite concentrations.  Cells have developed exquisite mechanisms to sense nutrient status and adjust their behavior to maintain growth or cope with stress, using a variety of mechanisms.