Alessandro Rosa | Ricerc@Sapienza

Publications

Title	Published on	Year
Editorial: The RNA Revolution in Embryonic Development and Cell Differentiation in Health and Disease	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY	2021
Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons	STEM CELL REPORTS	2021
A computational approach to investigate tdp-43 rna-recognition motif 2 c-terminal fragments aggregation in amyotrophic lateral sclerosis	BIOMOLECULES	2021
PiggyBac vectors in pluripotent stem cell research and applications	Methods in iPSC Technology	2021
Excess TPX2 interferes with microtubule disassembly and nuclei reformation at mitotic exit	CELLS	2020
Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System	CELLS	2020
Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling	SKELETAL MUSCLE	2020
FUS ALS-causative mutations impair FUS autoregulation and splicing factor networks through intron retention	NUCLEIC ACIDS RESEARCH	2020
Trans-generational epigenetic regulation associated with the amelioration of Duchenne Muscular Dystrophy	EMBO MOLECULAR MEDICINE	2020
HOTAIRM1 regulates neuronal differentiation by modulating NEUROGENIN 2 and the downstream neurogenic cascade	CELL DEATH & DISEASE	2020
Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding	SCIENTIFIC REPORTS	2020
Identification of molecular signatures in neural differentiation and neurological diseases using digital color-coded molecular barcoding	STEM CELLS INTERNATIONAL	2020
High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons	MOLECULAR AUTISM	2020
The Aurora-A/TPX2 axis directs spindle orientation in adherent human cells by regulating NuMA and microtubule stability	CURRENT BIOLOGY	2020
Conversion of Human Induced Pluripotent Stem Cells (iPSCs) into Functional Spinal and Cranial Motor Neurons Using PiggyBac Vectors	JOURNAL OF VISUALIZED EXPERIMENTS	2019
Mutant FUS and ELAVL4 (HuD) aberrant crosstalk in Amyotrophic Lateral Sclerosis	CELL REPORTS	2019
Construction of 3D in vitro models by bioprinting human pluripotent stem cells: Challenges and opportunities	BRAIN RESEARCH	2019
Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes	DISEASE MODELS & MECHANISMS	2019
3D bioprinted human cortical neural constructs derived from induced pluripotent stem cells	JOURNAL OF CLINICAL MEDICINE	2019
Influence of substrate stiffness on human induced pluripotent stem cells: Preliminary results	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS	2019

ERC

LS1_3
LS2_4
LS3_12
LS3_13
LS5_11

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Keywords

human induced pluripotent stem cells (hiPSC)

microRNA

RNA-binding proteins

motoneuron

amyotrophic lateral sclerosis (ALS)

brain organoid

Progetti di Ricerca

Generation and Coherent Antistokes Raman Scattering (CARS) characterization of a neuromuscular junction for Amyotrophic Lateral Sclerosis in vitro disease modeling
Identification and characterization of RNA binding proteins and non-coding RNAs with a role in human neural specification and neurodegenerative diseases