Alessandro Rosa | Ricerc@Sapienza

Publications

Title	Published on	Year
Ketogenic diet induces an inflammatory reactive astrocytes phenotype reducing glioma growth	CELLULAR AND MOLECULAR LIFE SCIENCES	2025
Selective Reduction of Ca2+ Entry Through the Human NMDA Receptor: a Quantitative Study by Simultaneous Ca2+ and Na+ Imaging	MOLECULAR NEUROBIOLOGY	2024
Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties	HELIYON	2024
AurkA/TPX2 co-overexpression in nontransformed cells promotes genome instability through induction of chromosome mis-segregation and attenuation of the p53 signalling pathway	BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE	2024
HuD impairs neuromuscular junctions and induces apoptosis in human iPSC and Drosophila ALS models	NATURE COMMUNICATIONS	2024
Digital color-coded molecular barcoding reveals dysregulation of common FUS and FMRP targets in soma and neurites of ALS mutant motoneurons	CELL DEATH DISCOVERY	2023
AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation	LIFE SCIENCE ALLIANCE	2023
CRISPR/Cas9 and piggyBac Transposon-Based Conversion of a Pathogenic Biallelic TBCD Variant in a Patient-Derived iPSC Line Allows Correction of PEBAT-Related Endophenotypes	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
Collective behavior and self-organization in neural rosette morphogenesis	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY	2023
The long noncoding RNA nHOTAIRM1 is necessary for differentiation and activity of iPSC-derived spinal motor neurons	CELL DEATH & DISEASE	2023
Culture of Human iPSC-Derived Motoneurons in Compartmentalized Microfluidic Devices and Quantitative Assays for Studying Axonal Phenotypes	Methods in Molecular Biology	2022
Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis	STEM CELL REPORTS	2022
Inducible motor neuron differentiation of human induced pluripotent stem cells in vivo	CELL PROLIFERATION	2022
Modelling skeletal pain harnessing tissue engineering	IN VITRO MODELS	2022
Emerging roles for the RNA-Binding protein HuD (ELAVL4) in nervous system diseases	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Harnessing microfluidic biofabrication and cell printing to develop an in vitro bone pain model	TISSUE ENGINEERING, PART A	2022
Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs	CELL DEATH & DISEASE	2021
Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor	CELL DEATH & DISEASE	2021
FUS-ALS mutants alter FMRP phase separation equilibrium and impair protein translation	SCIENCE ADVANCES	2021
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity	COMMUNICATIONS BIOLOGY	2021

ERC

LS1_3
LS2_4
LS3_12
LS3_13
LS5_11

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Keywords

human induced pluripotent stem cells (hiPSC)

microRNA

RNA-binding proteins

motoneuron

amyotrophic lateral sclerosis (ALS)

brain organoid

Progetti di Ricerca

Generation and Coherent Antistokes Raman Scattering (CARS) characterization of a neuromuscular junction for Amyotrophic Lateral Sclerosis in vitro disease modeling
Identification and characterization of RNA binding proteins and non-coding RNAs with a role in human neural specification and neurodegenerative diseases

Laboratori di ricerca

CU026 ps1 36 Biologia Molecolare