Roberto Contestabile | Ricerc@Sapienza

Publications

Title	Published on	Year
Identification of the pyridoxal 5′‐phosphate allosteric site in human pyridox(am)ine 5′‐phosphate oxidase	PROTEIN SCIENCE	2024
Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila	CELL DEATH & DISEASE	2024
STRUCTURE-BASED MECHANISM OF RIBOREGULATION OF THE METABOLIC ENZYME SHMT1	MOLECULAR CELL	2024
One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse	NATURE COMMUNICATIONS	2024
The Z isomer of pyridoxilidenerhodanine 5′‐phosphate is an efficient inhibitor of human pyridoxine 5′‐phosphate oxidase, a crucial enzyme in vitamin B6 salvage pathway and a potential chemotherapeutic target	THE FEBS JOURNAL	2024
The ubiquitous pyridoxal 5'-phosphate-binding protein is also an RNA-binding protein	PROTEIN SCIENCE	2024
A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila	JOURNAL OF CELLULAR PHYSIOLOGY	2023
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR	NUCLEIC ACIDS RESEARCH	2023
Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli. A pivotal enzyme in the vitamin B6 salvage pathway	THE FEBS JOURNAL	2023
Insights into the substrate specificity, structure, and dynamics of plant histidinol-phosphate aminotransferase (HISN6)	PLANT PHYSIOLOGY AND BIOCHEMISTRY	2023
4'-Deoxypyridoxine disrupts vitamin B6 homeostasis in Escherichia coli K12 through combined inhibition of cumulative B6 uptake and PLP-dependent enzyme activity	MICROBIOLOGY	2023
Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR	NUCLEIC ACIDS RESEARCH	2023
Cytosolic localization and in vitro assembly of human de novo thymidylate synthesis complex	THE FEBS JOURNAL	2022
Thiamine-dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo	JOURNAL OF NEUROCHEMISTRY	2022
Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K	JOURNAL OF CELLULAR PHYSIOLOGY	2022
Riboregulation as a new player in the control of cellular metabolism: clues from the cryo-EM structure of serine hydroxymethyltransferase-RNA complex		2022
Arabidopsis thaliana serine hydroxymethyltransferases: functions, structures, and perspectives	PLANT PHYSIOLOGY AND BIOCHEMISTRY	2022
Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability	PROTEIN SCIENCE	2022
Functional inactivation of drosophila GCK orthologs causes genomic instability and oxidative stress in a fly model of MODY-2	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
Knowns and unknowns of vitamin B6 metabolism in escherichia coli	ECOSAL PLUS	2021

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ERC

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KET

Life-science technologies & biotechnologies

Interessi di ricerca

Keywords

B vitamins

cell metabolism

enzyme

binding kinetics

Enzyme kinetics

homeostasis and regulation

Progetti di Ricerca

Structural and functional role of lysine residues in Escherichia coli YggS, a pivotal regulatory component of vitamin B6 metabolism.
Studies on the role of pyridoxine 5'-phosphate oxidase in vitamin B6 homeostasis
Determining the identity of the missing enzyme in human carnitine biosynthetic pathway
Role and mechanism of action of the human pyridoxal 5'-phosphate-binding protein (PLP-BP) in vitamin B6 metabolism. Molecular basis of PLP-BP-dependent epilepsy