Ricerc@Sapienza

AIM:
Neuromuscular junction (NMJ) represents the morphofunctional interface between muscle and nerve. Several chronic pathologies such as aging and neurodegenerative diseases, including muscular dystrophy and amyotrophic lateral sclerosis, display altered NMJ and functional denervation. However, the triggers and the molecular mechanisms underlying the dismantlement of NMJ remain unclear.
RESULTS:

To grow old well is not simple in our society. To grow old successfully and be bisexual it is a kind of challenge. Negative attitudes toward bisexuals have been documented among heterosexuals as well as homosexuals. Older bisexual adults may then experience various forms of discrimination which will lead to marginalization and invisibility. Forming and maintaining a bisexual identity in a sexually dichotomous culture is a complex and difficult task that calls for resilience to counter the isolation. Older bisexuals have many different types of relationships.

Aging seems to be associated with impairment of attentional network functioning. It is not known whether social information can modulate this age-related decline. We used three variants of Attention Network test to examine the age-related decline of attentional effects in response to stimuli with and without social-cognitive content. Three groups of younger, middle-aged, and older participants performed the ANT, using fish, drawings, or photographs of faces looking to the left or right as target and flanker stimuli.

Abstract
Background: In recent years, mechanistic, epidemiologic, and interventional studies have indicated beneficial
effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) against brain aging and age-related cognitive decline,
with the most consistent effects against Alzheimer’s disease (AD) confined especially in the early or prodromal
stages of the pathology.
In the present study, we investigated the action of n-3 PUFA supplementation on behavioral performances and

We have entered an era of a steep increase in the absolute and relative number of older
people. This well-come phenomenon represents a major challenge for health care. However, maturational
changes in sleep associated with aging do not easily appear as main factors, even though
sleep alterations in the aging process lead to many detrimental consequences. In this editorial paper,
we summarize the present knowledge about the main aging-related sleep modifications and their

Background and objectives: Electrical risk score (ERS) has been proposed as easy, inexpensive test to stratify of
sudden cardiac death (SCD) risk in subjects with normal left ventricular function. Potentially, aging, gender
and drugs can influence ERS affecting two on six electrical markers, particularly, those based on the repolarization.
Aim of this study was to establish aging, gender and drug therapy possible influences on ERS and mortality
in elderly patients.

Nowadays, organizations face the co-presence of three generations of workers (“baby boomers”, Xers and Yers). However, another generation will join the workforce in the next years: the generation Z. Accordingly, companies must be able to understand their characteristics and expectations, in order to manage their generation mix.

Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. The inflammatory phenotype of senescent cells was previously shown to be driven by cytoplasmic DNA. Here, we propose that cytoplasmic double-stranded RNA has a similar effect. We find that several cell types driven into senescence by different routes share an accumulation of long promoter RNAs and 3' gene extensions rich in retrotransposon sequences.

Purpose: Different authors have reported that aging could be associated with changes in obstructive sleep apnea (OSA) related parameters (apnea/hypopnea index, SpO2, reduction of daytime sleepiness, etc.), type of sleep and pattern of collapse. Regarding OSA severity in elderly patients, it is commonly believed that the AHI score tends to increase with aging.

One of the most common complaints among the elderly is the inability to understand speech in noisy environments. In many cases, these deficits are due to age-related hearing loss; however, some of the elderly that have difficulty hearing in noise have clinically normal pure-tone thresholds. While speech in noise testing is informative, it fails to identify specific frequencies responsible for the speech processing deficit.