Nowadays, organizations face the co-presence of three generations of workers (“baby boomers”, Xers and Yers). However, another generation will join the workforce in the next years: the generation Z. Accordingly, companies must be able to understand their characteristics and expectations, in order to manage their generation mix.
Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. The inflammatory phenotype of senescent cells was previously shown to be driven by cytoplasmic DNA. Here, we propose that cytoplasmic double-stranded RNA has a similar effect. We find that several cell types driven into senescence by different routes share an accumulation of long promoter RNAs and 3' gene extensions rich in retrotransposon sequences.
Purpose: Different authors have reported that aging could be associated with changes in obstructive sleep apnea (OSA) related parameters (apnea/hypopnea index, SpO2, reduction of daytime sleepiness, etc.), type of sleep and pattern of collapse. Regarding OSA severity in elderly patients, it is commonly believed that the AHI score tends to increase with aging.
One of the most common complaints among the elderly is the inability to understand speech in noisy environments. In many cases, these deficits are due to age-related hearing loss; however, some of the elderly that have difficulty hearing in noise have clinically normal pure-tone thresholds. While speech in noise testing is informative, it fails to identify specific frequencies responsible for the speech processing deficit.
Background The presence of white matter hyperintensities (WMHs) can impact on normal brain function by altering normal signal transmission and determining different symptoms.
Aim To evaluate the relationship between the presence of brainWMHs and the scores of speech perception test (SPT) in a sample of normal-hearing patients under 70 years of age.
Aim of this study was to characterize the effects of oral trehalose administration (2%w/v) on healthspan in old mice. Trehalose was administered in drinking water for 1 month to male and female C57BL/6N mice aged 25-months. After behavioral phenotyping (grip strength, beam walking and rotarod tests), autophagy (LC3-II/actin) and oxidative stress were tested in the cerebral cortex and gastrocnemius muscle.
Brain and sleep maturation covary across different stages of life. At the same time, dream generation and dream recall are intrinsically dependent on the development of neural systems. The aim of this paper is to review the existing studies about dreaming in infancy, adulthood, and the elderly stage of life, assessing whether dream mentation may reflect changes of the underlying cerebral activity and cognitive processes.
Sleep significantly changes across the lifespan, and several studies underline its crucial role in cognitive functioning. Similarly, mental activity during sleep tends to covary with age. This review aims to analyze the characteristics of dreaming and disturbing dreams at dierent age brackets. On the one hand, dreams may be considered an expression of brain maturation and cognitive development, showing relations with memory and visuo-spatial abilities.
Several findings support the activation hypothesis, positing that cortical arousal promotes
dream recall (DR). However, most studies have been carried out on young participants, while the
electrophysiological (EEG) correlates of DR in older people are still mostly unknown. We aimed to
test the activation hypothesis on 20 elders, focusing on the Non‐Rapid Eye Movement (NREM) sleep
stage. All the subjects underwent polysomnography, and a dream report was collected upon their
Background: Driving performance is strongly vulnerable to drowsiness and vigilance
fluctuations. Excessive sleepiness may alter concentration, alertness, and reaction times. As people
age, sleep undergoes some changes, becoming fragmented and less deep. However, the effects of
these modifications on daily life have not been sufficiently investigated. Recently, the assessment of
sleepiness became mandatory in Europe for people at risk who need the driving license release.
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