Ricerc@Sapienza

Churches are an essential part of the historical and architectural heritage of several countries, and various earthquakes have highlighted the significant seismic vulnerability of ancient religious buildings. On August 24, 2016, a seismic sequence started in Central Italy with a magnitude 6.0 event. Nine events with magnitude ≥ 5.0 occurred between that date and January 18, 2017.

In the framework of the European Union MAXSIMA project, the safety of the steam generator (SG) adopted in the primary loop of the Heavy Liquid Metal Fast Reactor has been studied investigating the consequences and damage propagation of a SG tube rupture event and characterizing leak rates from typical cracks. Instrumentation able to promptly detect the presence of a crack in the SG tubes may be used to prevent its further propagation, which would lead to a full rupture of the tube.

Introduction: The safety of subcutaneous immunotherapy (SCIT), and particularly the dramatic issue of fatal reactions, has been an obstacle that limited the implementation of a therapy with unique characteristics of action on the causes of allergy. The introduction of sublingual immunotherapy (SLIT) was aimed at solving safety problems while maintaining clinical efficacy. Areas covered: For more than 20 years, SLIT has been based on allergen extracts in drops at low average doses.

BACKGROUND: At the time of subcutaneous implantable cardioverter-defibrillator (S-ICD) implantation, successful termination of ventricular fibrillation (VF) is confirmed. A previous study reported cases of prolonged time to therapy during defibrillation testing.
OBJECTIVE: We sought to evaluate the time to therapy, identify possible predictors of delay and investigate the impact of delayed therapy on VF conversion.
METHODS: We analyzed consecutive S-ICD patients who underwent initial conversion testing at a shock energy of 65J in 53 Italian centers.

Novel ionic liquids (ILs), which were functionalized with ether oxygens to suppress crystallization and with bis(fluorosulfonyl)imide (FSI) anions to improve ionic conductivity, were synthesized and compared. Electrolyte mixtures were prepared by adding LiFSI to N-ethoxyethyl-N-methylpiperidinium FSI ([P 1,2O2 ][FSI]) and N-ethoxyethyl-N-methylmorpholinium FSI ([M 1,2O2 ][FSI]) in ratio of 1:9 (mol/mol). The electrolyte mixtures were found to exhibit a glass transition temperature between −71 and −93 °C and a decomposition temperature higher than 266 °C.

We demonstrate that the addition of 1-butyl-1-methylpyrrolidinium hexafluorophosphate ([Py14]PF6)to1.0 M LiPF6in ethylene carbonate-dimethyl carbonate (LP30) widens the temperature range, in which theelectrolyte mixtures are ion conductive and safe. Specifically, at the concentrations of [Py14]PF6above50 wt%, the electrolyte mixtures exhibit aflash point higher than room temperature and fulfill the re-quirements of liquids having controlledflammability.

The skin prick test (SPT) is the most common test for the diagnosis of allergy. SPT is performed by pricking the skin, usually in the volar surface of the forearm, with a lancet through a drop of an allergen extract and is usually the first choice test in the diagnostic workup for allergic diseases because of its reliability, safety, convenience and low cost. SPT is minimally invasive and has the advantage of testing multiple allergens in 15 to 20 min.

SummaryAllergen immunotherapy (AIT) is aimed at inducing tolerance to allergens, such as pollens, dust mites or moulds, by administering increasing amounts of the causative allergen through subcutaneous or sublingual route. The evidence of efficacy of AIT is high, but the issue of safety, especially for the subcutaneous route, must be taken into account.

Background: Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneu- monia the most frequent cause of death in COVID-19 patients.

Feature at a glance: Although a lack of safety features is often reported as the most important factor in tractor accidents, an accident per se is the outcome of many elements, including the amount of attentional control operators exert over the driving task. The lack of active attentional control is sometimes referred as “absentmindedness,” and many studies have investigated this phenomenon as the expression of individual differences.