MNC - Molecular Networks in Cancer Unit
Alterations in Notch signaling play a crucial role in cancer development and progression. Depending on the cancer context, Notch signaling can act as either an oncogene or a tumor suppressor. Understanding the mechanisms underlying this dual role is essential for identifying novel molecular targets and developing innovative therapeutic strategies.
Our research laboratory integrates biochemical, molecular, and cellular biology approaches to investigate the mechanisms regulating the Notch pathway at the transcriptional, epigenetic, and post-translational levels, as well as its implications in cancer biology. Particular attention is given to the interplay between Notch and other oncogenic pathways.
In addition, we explore novel natural compounds and their derivatives with modulatory activity on key signaling, including Notch, to pave the way for the development of innovative targeted cancer therapies.
Responsabile del Gruppo
Rocco Palermo
