PARylation as a Mediator of Epigenetic Remodelling: Integrating DNA Methylation, Oxidative Stress and Inflammation in Human Disease
PARylation, a post-translational modification catalyzed by PARP-1, represents a central mechanism connecting oxidative stress, inflammation, and epigenetic regulation of gene expression.
Excessive PARP-1 activation under metabolic or oxidative stress conditions alters NAD⁺ homeostasis and interferes with the activity of DNA methyltransferases (DNMTs) and TET dioxygenases, thereby reshaping the balance between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC).
These alterations contribute to widespread transcriptional reprogramming affecting metabolic and inflammatory pathways, promoting cellular dysfunction.
By integrating molecular, epigenetic, and redox biology approaches, the research group aims to define how PARylation-dependent mechanisms drive the crosstalk between oxidative stress and epigenetic remodeling, and to identify potential biomarkers and therapeutic targets for restoring redox–epigenetic balance in human disease.
Responsabile del Gruppo
Anna Reale
