Long term immunization after mRNA covid-19 vaccine in subjects with obesity: impact of adiposity parameters, cardiometabolic conditions and risk factors
| Componente | Categoria |
|---|---|
| Lucio Gnessi | Aggiungi Tutor di riferimento (Professore o Ricercatore afferente allo stesso Dipartimento del Proponente) |
Lately, the prevalence of obesity has increased exponentially, reaching the characteristics of a real epidemic with more than 2 billion people worldwide being affected. Excess fat leads to numerous complications, the most well-known being type 2 diabetes, obstructive sleep apnea syndrome, non-alcoholic fatty liver disease and cardiovascular disease. Recently, we have shown that visceral fat is a major risk factor for the development of a more severe Covid-19 infection and lower antibody titers right after COVID-19 mRNA vaccination.
The aim of this study is to investigate whether obesity and poor metabolic health are associated with poor seroconversion and lower cell mediated immune response several months after a COVID-19 mRNA vaccine administration.
We have previously enrolled 30 subjects with normal weight and 30 subjects with obesity. They have undergone a DEXA scan, routine blood tests, sars-Cov-2 Ab before and 7-30 days after the second inoculation. To verify whether the observed lower antibody titers short term suggest a blunted or less durable immune response, serum antibodies and cell mediated response to SARS-CoV-2 will be assessed 9 months after the vaccination in the same subjects. Eventual COVID-19 known exposure and infection in the preceding months will also be recorded.