Targeting BK channels to potentiate temozolomide effect under hypoxia in glioblastoma cells
Anno
2020
Proponente Antonella Calogero - Professore Ordinario
Sottosettore ERC del proponente del progetto
LS4_6
Componenti gruppo di ricerca
| Componente | Categoria |
|---|---|
| Paolo Rosa | Dottorando/Assegnista/Specializzando componente non strutturato del gruppo di ricerca |
Abstract
Glioblastomas (GBMs) are brain tumors of glial origin characterized by a heavy hypoxic microenvironment, which correlates with tumor aggressiveness. GBM cells abundantly express large-conductance, calcium-activated potassium (BK) channels and, since hypoxia modulates their activity in GBM cells, the aim of the present project is to explore their role in response to temozolomide (TMZ, the standard of care for all GBM patients) and to better understand the molecular mechanisms underlying the effect of the hypoxic microenvironment on BK channels-dependent drug resistance of GBM cells.
ERC
LS3_7, LS7_4, LS3_8
Keywords:
BASI BIOLOGICHE DEL CANCRO, CHEMIOTERAPIA, ONCOLOGIA