Adding pieces to the puzzle of autoimmune atrophic gastritis (AAG) and gastric neoplastic risk: role of gastric metaplasia, serological and immunological response, and gastrointestinal microbiota composition
| Componente | Categoria |
|---|---|
| Bruno Annibale | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Gianluca Esposito | Dottorando/Assegnista/Specializzando componente non strutturato del gruppo di ricerca / PhD/Assegnista/Specializzando member non structured of the research group |
| Paolo Mercantini | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Vito Domenico Corleto | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Componente | Qualifica | Struttura | Categoria |
|---|---|---|---|
| Davidson Howard W | Professor of Pediatrics & Immunology/Microbiology | Barbara Davis Center for Childhood Diabetes University of Colorado Anschutz Medical Campus, Aurora, USA | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Norman Gary | Director of Research and Development | Inova Diagnostics, San Diego, CA 92131, USA | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Lenti Marco V | Researcher gastroenterologist | IRCCS Policlinico San Matteo, Pavia, Italy | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Borro Marina | Clinical pathologist | Department Advanced Molecular Diagnosis, Sant'Andrea Hospital, Rome | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Palumbo Antonio | Pathologist | Oncological Referral Center, Gastrointestinal Oncology, Aviano (PN), Italy | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Lampasona Vito | Senior scientist | San Raffaele Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
Autoimmune atrophic gastritis(AAG) is characterized by reduced gastric acid secretion and increased gastric cancer(GC) risk. Parietal cell(PCA) and intrinsic factor autoantibodies(IFA) are considered markers for AAG; the role of pepsinogens, gastrin, and Helicobacter pylori(Hp) antibodies in the noninvasive AAG assessment is not established. The diagnostic performance of Narrowband imaging(NBI) and blue light imaging(BLI) electronic chromoendoscopy(EC) for gastric metaplasia may be improvable by artificial intelligence(AI) algorithms. Hp infection may be found in AAG, challenging differential diagnosis with Hp-AG. Distinctive inflammatory-metaplastic patterns between AAG and Hp-AG are not clear. Gastric dysbiosis may have a role in the multifactorial gastric carcinogenesis. AAG might be a model to investigate hypochlorhydria consequences on colonic microbiota composition.
This project is composed of 5 parts:
1. To investigate AAG prevalence and usefulness/feasibility of a proactive case-finding strategy for AAG by assessing in healthy blood donors serological markers of AAG (PCA) and gastric atrophy (pepsinogen I) and Hp.
2. To investigate in AAG patients the role of autoantibodies towards IFA by LIPS.
3. To investigate in AAG patients the applicability of AI-assisted-EC as a computer-aided diagnostic system to assess gastric metaplasia (intestinal and pseudopyloric) compared to biopsy-based histopathological markers.
4. To investigate in AAG patients the role of Hp infection by assessing seroreactivity against Hp-specific antigens and the immunophenotype of the gastric mucosal inflammatory response and metaplastic changes.
5. To investigate in AAG patients the role of gastric-colonic microbiota composition as possible cofactors associated with different clinical outcomes like micronutrient deficiencies, gastrointestinal symptoms, and gastric neoplastic complications.