Endometriosis is one of the most frequent benign gynecological diseases and it is defined by the histological presence of endometrial glands and stroma outside the uterine cavity.The multifactorial etiopathogenesis of endometriosis appears to be very complex and poorly understood, involving a variety of environmental, immune and genetic factors. Several studies suggest that peritoneal fluid is a key inflammatory environment in the development and progression of the disease (Caserta et al., 2014). The principal symptom is chronic pelvic pain, which can take on different forms according to the location and seriousness of the pathology, and can manifest as dyspareunia, dyschezia, dysmenorrhea, lower urinary tract syndrome. It is also a major cause of infertility, which in turn causes psychological stress, low self-esteem and depression. These symptoms have a negative effect on the woman's overall quality of life (Caserta et al., 2015).
Objective of this study would be to evaluate the levels of various proinflammatory cytokines in the serum and peritoneal fluid of women with and without endometriosis, and to correlate these levels with the disease stage and pain symptoms, and to analyze the disease by a bio-psycho-social approach.
