Design, synthesis and biological activity of new benzofuran derivatives as dual-target-directed monoamine oxidase B (MAO-B) and Acetylcholinesterase (AChE) inhibitors for neurodegenerative disorders.
Monoaminooxidases and Acetylcholinesterases plays a significant role in neurodegenerative desorders. Due to this relevant role in Alzheimer (AD) and Parkinson's Disease's (PD), a number of inhibitors has been reported to date.
More importantly, dual MAO and AChE inhibitors could show a uniquely favorable profile of pharmacologic action with an improved therapeutic window relative to single MAO or AChE inhibitors. Aims of this project are to design new inhibitors as therapeutic tools for neurodegenerative desorders and to perform a virtual screening for identifying new inhibitors ; to explore their hMAO-A and hMAO-B as well as AChE inhibitory potential respect to single-target inhibitors. The new produced molecules will be performed to define antioxidant activity.