Paola Chimenti

Pubblicazioni

Titolo Pubblicato in Anno
Novel therapeutic opportunities for Toxoplasma gondii, Trichomonas vaginalis, and Giardia intestinalis infections EXPERT OPINION ON THERAPEUTIC PATENTS 2023
Novel Insights on Human Carbonic Anhydrase Inhibitors Based on Coumalic Acid: Design, Synthesis, Molecular Modeling Investigation, and Biological Studies INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Novel insights on saccharin- and acesulfame-based carbonic anhydrase inhibitors: design, synthesis, modelling investigations and biological activity evaluation JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2020
Phytochemical analyses and pharmacological screening of Neem oil SOUTH AFRICAN JOURNAL OF BOTANY 2019
Design, synthesis, docking studies and monoamine oxidase inhibition of a small library of 1-acetyl- and 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazoles MOLECULES 2019
4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2019
Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2017
Antimicrobial activity, synergism and inhibition of germ tube formation by Crocus sativus-derived compounds against Candida spp JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2016
Novel 1,3-thiazolidin-4-one derivatives as promising anti-Candida agents endowed with anti-oxidant and chelating properties EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2016
Inhibition of human monoamine oxidase: biological and molecular modeling studies on selected natural flavonoids JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2016
(Thiazol-2-yl)hydrazone derivatives from acetylpyridines as dual inhibitors of MAO and AChE: synthesis, biological evaluation and molecular modeling studies JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2015
New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: Biological evaluation and molecular modelling studies BIOORGANIC & MEDICINAL CHEMISTRY 2015

ERC

  • LS1
  • LS7_4
  • LS7_7
  • PE4_2
  • PE4_5
  • PE5

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Sintesi di composti dotati di attività inibitrice selettiva sulle monoamminoossidasi, MAO-A e MAO-B. Separazione mediante HPLC stereoselettivo di molecole chirali attive sulle MAO. Sintesi di composti attivi sull’Helicobacter pylori, su ceppi di Candida e su Toxoplasma. Sintesi di composti attivi come inibitori/modulatori delle istone acetiltransferasi (HAT) e loro possibili applicazioni nel campo dell’epigenetica. inibitori della hCAs

Keywords

drug design and discovery
anticancer agent
Chalcone Neurodegenerative diseases Monoamine oxidase Selective MAO-B inhibitors MTDL Natural compounds

Progetti di Ricerca

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