Modulating gut-brain interactions to affect glioma growth.
| Componente | Categoria |
|---|---|
| Giuseppina D'Alessandro | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Francesca Grassi | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Silvia Di Angelantonio | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Fabrizio Mainiero | Componenti strutturati del gruppo di ricerca / Structured participants in the research project |
| Componente | Qualifica | Struttura | Categoria |
|---|---|---|---|
| Stefano Garofalo | AIRC fellow | Molecular Medicine Sapienza | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Clotilde Lauro | Technician | Physiology and Pharmacology Sapienza | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Maria Amalia Di Castro | Post Doc | University of Losanna | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Alessandro Felici | Technician | Physiology and Pharmacology Sapienza | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
| Giusi Chece | Technician | Physiology and Pharmacology Sapienza | Altro personale aggregato Sapienza o esterni, titolari di borse di studio di ricerca / Other aggregate personnel Sapienza or other institution, holders of research scholarships |
Gut microbes communicate in bidirectional way with the brain, with mechanisms that involve the hypothalamic-pituitary-adrenal axis, several neurotransmitters, and microbial metabolites. Immune system lies at the interface among the two systems, mediating part of the effects of microbe-released factors on brain functions. Microbial composition of the gut is influenced by a variety of issues including diet, environmental factors and antibiotic use. The same factors play key roles in brain functions, modulating plasticity processes via modification of brain microenvironment. Recent evidence demonstrate that gut-resident microbes may modulate tumor microenvironment, with efffects on therapy efficacy.
We have recently demonstrated that, in mouse models of brain tumor, the housing conditions modulate brain tumor microenvironment, both with immune and non immune mechanisms.
In this project we want to verify the hypothesis that gut microbes signal to the brain, modifying brain tumor microenvironment and that these signals are integrated with those coming from the external environment, affecting innate immune system activation, and contributing to regulate brain tumor growth.