Structural elucidation and antimicrobial characterization of novel diterpenoids from fabiana densa var. ramulosa
01 Pubblicazione su rivista
Quaglio Deborah, Corradi Silvia, Erazo Silvia, Vergine Valeria, Berardozzi Simone, Sciubba Fabio, Cappiello Floriana, Crestoni Maria Elisa, Ascenzioni Fiorentina, Imperi Francesco, Delle Monache Franco, Mori Mattia, Loffredo Maria Rosa, Ghirga Francesca, Casciaro Bruno, Botta Bruno, Mangoni Maria Luisa
ISSN: 1948-5875
Novel diterpenoids were isolated from the extracts of Fabiana densa var. ramulosa and found to display a selective activity against Gram-positive bacterial strains with negligible cytotoxicity toward human keratinocytes. This study highlighted the role played by the acidic group at C18 of the tetracyclic ent-beyerene scaffold for antibacterial effects and how the length and flexibility of the alkyl chain between the two carbonyl groups are crucial factors to increase the antimicrobial activity of the molecules, supporting the development of natural products from F. densa and their derivatives for treatment of microbial infections.