Carmona-Gutierrez Didac, Bauer Maria Anna, Zimmermann Andreas, Aguilera Andrés, Austriaco Nicanor, Ayscough Kathryn, Balzan Rena, Bar-Nun Shoshana, Barrientos Antonio, Belenky Peter, Blondel Marc, Braun Ralf J., Breitenbach Michael, Burhans William C., Buettner Sabrina, Cavalieri Duccio, Chang Michael, Cooper Katrina F., Côrte-Real Manuela, Costa Vítor, Cullin Christophe, Dawes Ian, Dengjel Jörn, Dickman Martin B., Eisenberg Tobias, Fahrenkrog Birthe, Fasel Nicolas, Froehlich Kai-Uwe, Gargouri Ali, Giannattasio Sergio, Goffrini Paola, Gourlay Campbell W., Grant Chris M., Greenwood Michael T., Guaragnella Nicoletta, Heger Thomas, Heinisch Juergen, Herker Eva, Herrmann Johannes M., Hofer Sebastian, Jiménez-Ruiz Antonio, Jungwirth Helmut, Kainz Katharina, Kontoyiannis Dimitrios P., Ludovico Paula, Manon Stéphen, Martegani Enzo,
Mazzoni Cristina, Megeney Lynn A., Meisinger Chris, Nielsen Jens, Nystroem Thomas, Osiewacz Heinz D., Outeiro Tiago F., Park Hay-Oak, Pendl Tobias, Petranovic Dina, Picot Stephane, Polčic Peter, Powers Ted, Ramsdale Mark, Rinnerthaler Mark, Rockenfeller Patrick, Ruckenstuhl Christoph, Schaffrath Raffael, Segovia Maria, Severin Fedor F., Sharon Amir, Sigrist Stephan J., Sommer-Ruck Cornelia, Sousa Maria João, Thevelein Johan M., Thevissen Karin, Titorenko Vladimir, Toledano Michel B., Tuite Mick, Voegtle F. -Nora, Westermann Benedikt, Winderickx Joris, Wissing Silke, Woelfl Stefan, Zhang Zhaojie J., Zhao Richard Y., Zhou Bing, Galluzzi Lorenzo, Kroemer Guido, Madeo Frank
Elucidating the biology of yeast in its full complexity has major implications for science, medicine and industry. One of the most critical processes determining yeast life and physiology is cel- lular demise. However, the investigation of yeast cell death is a relatively young field, and a widely accepted set of concepts and terms is still missing. Here, we propose unified criteria for the defi- nition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria. Specifically, we provide consensus guidelines on the differ- ential definition of terms including apoptosis, regulated necrosis, and autophagic cell death, as we refer to additional cell death rou- tines that are relevant for the biology of (at least some species of) yeast. As this area of investigation advances rapidly, changes and extensions to this set of recommendations will be implemented in the years to come. Nonetheless, we strongly encourage the au- thors, reviewers and editors of scientific articles to adopt these collective standards in order to establish an accurate framework for yeast cell death research and, ultimately, to accelerate the pro- gress of this vibrant field of research.
